Rheumatoid Arthritis is Associated with IgG Antibodies to Human Endogenous Retrovirus Gag Matrix: A Potential Pathogenic Mechanism of Disease?

2.00
Hdl Handle:
http://hdl.handle.net/2436/333571
Title:
Rheumatoid Arthritis is Associated with IgG Antibodies to Human Endogenous Retrovirus Gag Matrix: A Potential Pathogenic Mechanism of Disease?
Authors:
Nelson, Paul N; Roden, Denise; Nevill, Alan M.; Freimanis, Graham L; Trela, Malgorzata; Ejtehadi, Hora Davari; Bowman, Simon; Axford, John; Veitch, Andy M; Tugnet, Nicola; Rylance, Paul B
Abstract:
Human endogenous retrovirus (HERV)-K10 has been implicated in the etiology and pathogenesis of rheumatoid arthritis (RA). A secondary immune response to this virus might suggest an antigen-driven response in patients. The Gag region of HERV-K10 could provide a key epitope important for immunological reactivity. We investigated the presence of IgG antibodies to this region and assessed its significance in RA.
Citation:
Rheumatoid Arthritis is Associated with IgG Antibodies to Human Endogenous Retrovirus Gag Matrix: A Potential Pathogenic Mechanism of Disease? 2014, 41 (10):1952-60 J. Rheumatol.
Journal:
The Journal of rheumatology
Issue Date:
Oct-2014
URI:
http://hdl.handle.net/2436/333571
DOI:
10.3899/jrheum.130502
PubMed ID:
25225282
Type:
Article
Language:
en
ISSN:
0315-162X
Appears in Collections:
Sport, Exercise and Health Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorNelson, Paul Nen_GB
dc.contributor.authorRoden, Deniseen_GB
dc.contributor.authorNevill, Alan M.en_GB
dc.contributor.authorFreimanis, Graham Len_GB
dc.contributor.authorTrela, Malgorzataen_GB
dc.contributor.authorEjtehadi, Hora Davarien_GB
dc.contributor.authorBowman, Simonen_GB
dc.contributor.authorAxford, Johnen_GB
dc.contributor.authorVeitch, Andy Men_GB
dc.contributor.authorTugnet, Nicolaen_GB
dc.contributor.authorRylance, Paul Ben_GB
dc.date.accessioned2014-11-03T12:17:37Z-
dc.date.available2014-11-03T12:17:37Z-
dc.date.issued2014-10-
dc.identifier.citationRheumatoid Arthritis is Associated with IgG Antibodies to Human Endogenous Retrovirus Gag Matrix: A Potential Pathogenic Mechanism of Disease? 2014, 41 (10):1952-60 J. Rheumatol.en_GB
dc.identifier.issn0315-162X-
dc.identifier.pmid25225282-
dc.identifier.doi10.3899/jrheum.130502-
dc.identifier.urihttp://hdl.handle.net/2436/333571-
dc.description.abstractHuman endogenous retrovirus (HERV)-K10 has been implicated in the etiology and pathogenesis of rheumatoid arthritis (RA). A secondary immune response to this virus might suggest an antigen-driven response in patients. The Gag region of HERV-K10 could provide a key epitope important for immunological reactivity. We investigated the presence of IgG antibodies to this region and assessed its significance in RA.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to The Journal of rheumatologyen_GB
dc.subjectRHEUMATOID ARTHRITISen_GB
dc.subjectENZYME LINKED IMMUNOSORBENT ASSAYen_GB
dc.subjectHUMAN ENDOGENOUS RETROVIRUSen_GB
dc.subjectBIOINFORMATICSen_GB
dc.titleRheumatoid Arthritis is Associated with IgG Antibodies to Human Endogenous Retrovirus Gag Matrix: A Potential Pathogenic Mechanism of Disease?en
dc.typeArticleen
dc.identifier.journalThe Journal of rheumatologyen_GB

Related articles on PubMed

All Items in WIRE are protected by copyright, with all rights reserved, unless otherwise indicated.