2.50
Hdl Handle:
http://hdl.handle.net/2436/313455
Title:
Plasma irisin levels predict telomere length in healthy adults
Authors:
Rana, Karan S.; Arif, Muhammad ( 0000-0002-3769-3838 ) ; Hill, Eric J.; Aldred, Sarah; Nagel, David A.; Nevill, Alan M.; Randeva, Harpal S.; Bailey, Clifford J.; Bellary, Srikanth; Brown, James E.
Abstract:
The ageing process is strongly influenced by nutrient balance, such that modest calorie restriction (CR) extends lifespan in mammals. Irisin, a newly described hormone released from skeletal muscles after exercise, may induce CR-like effects by increasing adipose tissue energy expenditure. Using telomere length as a marker of ageing, this study investigates associations between body composition, plasma irisin levels and peripheral blood mononuclear cell telomere length in healthy, non-obese individuals. Segmental body composition (by bioimpedance), telomere length and plasma irisin levels were assessed in 81 healthy individuals (age 43±15.8 years, BMI 24.3±2.9 kg/m2). Data showed significant correlations between log-transformed relative telomere length and the following: age (p<0.001), height (p=0.045), total body fat percentage (p=0.031), abdominal fat percentage (p=0.038), visceral fat level (p<0.001), plasma leptin (p=0.029) and plasma irisin (p=0.011), respectively. Multiple regression analysis using backward elimination revealed that relative telomere length can be predicted by age (b=−0.00735, p= 0.001) and plasma irisin levels (b=0.04527, p=0.021). These data support the view that irisin may have a role in the modulation of both energy balance and the ageing process.
Citation:
Plasma irisin levels predict telomere length in healthy adults 2014 AGE
Publisher:
Springer Verlag
Journal:
Age
Issue Date:
Apr-2014
URI:
http://hdl.handle.net/2436/313455
DOI:
10.1007/s11357-014-9620-9
Additional Links:
http://link.springer.com/10.1007/s11357-014-9620-9
Type:
Article
Language:
en
ISSN:
0161-9152; 1574-4647
Appears in Collections:
Sport, Exercise and Health Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorRana, Karan S.en_GB
dc.contributor.authorArif, Muhammaden_GB
dc.contributor.authorHill, Eric J.en_GB
dc.contributor.authorAldred, Sarahen_GB
dc.contributor.authorNagel, David A.en_GB
dc.contributor.authorNevill, Alan M.en_GB
dc.contributor.authorRandeva, Harpal S.en_GB
dc.contributor.authorBailey, Clifford J.en_GB
dc.contributor.authorBellary, Srikanthen_GB
dc.contributor.authorBrown, James E.en_GB
dc.date.accessioned2014-02-27T11:54:59Z-
dc.date.available2014-02-27T11:54:59Z-
dc.date.issued2014-04-
dc.identifier.citationPlasma irisin levels predict telomere length in healthy adults 2014 AGEen_GB
dc.identifier.issn0161-9152-
dc.identifier.issn1574-4647-
dc.identifier.doi10.1007/s11357-014-9620-9-
dc.identifier.urihttp://hdl.handle.net/2436/313455-
dc.description.abstractThe ageing process is strongly influenced by nutrient balance, such that modest calorie restriction (CR) extends lifespan in mammals. Irisin, a newly described hormone released from skeletal muscles after exercise, may induce CR-like effects by increasing adipose tissue energy expenditure. Using telomere length as a marker of ageing, this study investigates associations between body composition, plasma irisin levels and peripheral blood mononuclear cell telomere length in healthy, non-obese individuals. Segmental body composition (by bioimpedance), telomere length and plasma irisin levels were assessed in 81 healthy individuals (age 43±15.8 years, BMI 24.3±2.9 kg/m2). Data showed significant correlations between log-transformed relative telomere length and the following: age (p<0.001), height (p=0.045), total body fat percentage (p=0.031), abdominal fat percentage (p=0.038), visceral fat level (p<0.001), plasma leptin (p=0.029) and plasma irisin (p=0.011), respectively. Multiple regression analysis using backward elimination revealed that relative telomere length can be predicted by age (b=−0.00735, p= 0.001) and plasma irisin levels (b=0.04527, p=0.021). These data support the view that irisin may have a role in the modulation of both energy balance and the ageing process.en_GB
dc.language.isoenen
dc.publisherSpringer Verlagen_GB
dc.relation.urlhttp://link.springer.com/10.1007/s11357-014-9620-9en_GB
dc.rightsArchived with thanks to AGEen_GB
dc.subjectIrisinen_GB
dc.subjectTelomere lengthen_GB
dc.subjectAgeingen_GB
dc.subjectBody compositionen_GB
dc.subjectAdipose tissueen_GB
dc.subjectMuscleen_GB
dc.titlePlasma irisin levels predict telomere length in healthy adultsen
dc.typeArticleen
dc.identifier.journalAgeen_GB
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