A rhegnylogic strategy for the synthesis of signal transduction modulatory, cell penetrating peptides

2.50
Hdl Handle:
http://hdl.handle.net/2436/30273
Title:
A rhegnylogic strategy for the synthesis of signal transduction modulatory, cell penetrating peptides
Authors:
Jones, Sarah; Ostlund, Pernilla; Langel, Ulo; Zorko, Matjaz; Nicholl, Iain D.; Howl, John D.
Other Titles:
In: Rolka, R., Rekowski, P. & Siberring, J. (Eds.), Peptides 2006 : Proceedings of the Twenty-Ninth European Peptide Symposium, Gdansk, Poland, 3 - 8 Sept. 2006, No. 0212
Abstract:
INTRODUCTION: Many cell-penetrating peptides (CPP) have been utilised as biologically inert vectors. A majority of these studies employ sychnologically organised constructs in which a bioactive cargo (message) is chemically conjugated to the CPP (address). Previously, we have adopted a sychnologic strategy to modulate intracellular signal transduction. Using chimeric constructs composed of the CPP transportan 10, conjugated to partial sequences that correspond to functional domains of signal transduction proteins, we have selectively modulated a variety of cellular activities including secretion and activation of p42/p44 mitogen-activated protein kinases [1, 2]. However, a QSAR-based algorithm can now be used to predict CPP that reside within the primary sequences of proteins [3]. We have adapted this strategy to identify CPP within signal transducing proteins including functional domains that govern protein-protein interactions. Data presented herein indicate that it is now feasible to identify rhegnylogic sequences, containing vectoral-independent discontinuously organised pharmacophores, that are cell penetrant modulators of signal transduction pathways.
Citation:
Journal of Peptide Science, 12(Suppl 1)
Publisher:
Wiley InterScience
Journal:
Journal of Peptide Science
Issue Date:
2006
URI:
http://hdl.handle.net/2436/30273
Additional Links:
http://www.29eps.com/proceedings.asp; http://www3.interscience.wiley.com/journal/112771385/issue
Type:
Article; Meetings & Proceedings
Language:
en
ISSN:
1075-2617; 1099-1387
ISBN:
978-965-555-297-3
Appears in Collections:
Cancer Research Group; Molecular Pharmacology Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorJones, Sarah-
dc.contributor.authorOstlund, Pernilla-
dc.contributor.authorLangel, Ulo-
dc.contributor.authorZorko, Matjaz-
dc.contributor.authorNicholl, Iain D.-
dc.contributor.authorHowl, John D.-
dc.date.accessioned2008-06-20T16:15:03Z-
dc.date.available2008-06-20T16:15:03Z-
dc.date.issued2006-
dc.identifier.citationJournal of Peptide Science, 12(Suppl 1)en
dc.identifier.isbn978-965-555-297-3-
dc.identifier.issn1075-2617-
dc.identifier.issn1099-1387-
dc.identifier.urihttp://hdl.handle.net/2436/30273-
dc.description.abstractINTRODUCTION: Many cell-penetrating peptides (CPP) have been utilised as biologically inert vectors. A majority of these studies employ sychnologically organised constructs in which a bioactive cargo (message) is chemically conjugated to the CPP (address). Previously, we have adopted a sychnologic strategy to modulate intracellular signal transduction. Using chimeric constructs composed of the CPP transportan 10, conjugated to partial sequences that correspond to functional domains of signal transduction proteins, we have selectively modulated a variety of cellular activities including secretion and activation of p42/p44 mitogen-activated protein kinases [1, 2]. However, a QSAR-based algorithm can now be used to predict CPP that reside within the primary sequences of proteins [3]. We have adapted this strategy to identify CPP within signal transducing proteins including functional domains that govern protein-protein interactions. Data presented herein indicate that it is now feasible to identify rhegnylogic sequences, containing vectoral-independent discontinuously organised pharmacophores, that are cell penetrant modulators of signal transduction pathways.en
dc.language.isoenen
dc.publisherWiley InterScienceen
dc.relation.urlhttp://www.29eps.com/proceedings.aspen
dc.relation.urlhttp://www3.interscience.wiley.com/journal/112771385/issueen
dc.subjectPeptidesen
dc.subjectCPPen
dc.subjectCell Penetrating Peptides (CPP)en
dc.subjectSignal Transductionen
dc.subjectMolecular Biologyen
dc.subjectRhegnylogic strategyen
dc.subjectChimerismen
dc.titleA rhegnylogic strategy for the synthesis of signal transduction modulatory, cell penetrating peptidesen
dc.title.alternativeIn: Rolka, R., Rekowski, P. & Siberring, J. (Eds.), Peptides 2006 : Proceedings of the Twenty-Ninth European Peptide Symposium, Gdansk, Poland, 3 - 8 Sept. 2006, No. 0212en
dc.typeArticleen
dc.typeMeetings & Proceedingsen
dc.identifier.journalJournal of Peptide Scienceen
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