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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Molecular Immunology Research Group  > Effect of material deprivation on Epstein-Barr virus infection in Hodgkin's disease in the West Midlands.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/30254
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Title: Effect of material deprivation on Epstein-Barr virus infection in Hodgkin's disease in the West Midlands.
Authors: Flavell, Joanne R.
Constandinou, C.
Lowe, D.
Scott, K.
Newey, C.
Evans, D.
Dutton, A.
Simmons, S.
Smith, Richard
Crocker, John
Young, Lawrence S.
Murray, Paul G.
Citation: British Journal of Cancer, 80(3-4): 604-608
Publisher: nature.com
Journal: British Journal of Cancer
Issue Date: 1999
URI: http://hdl.handle.net/2436/30254
DOI: 10.1038/sj.bjc.6690398
PubMed ID: 10408873
Additional Links: http://www.nature.com/bjc/journal/v80/n3/abs/6690398a.html
Abstract: We have used Townsend scores from postcode data to compare levels of material deprivation and Epstein-Barr virus (EBV)-positivity for 223 patients diagnosed with Hodgkin's disease (HD) in the period 1981-1997. The presence of EBV in HD tumours was determined using in situ hybridization to target the abundantly expressed EBV early RNAs. EBV was detected in the malignant Hodgkin and Reed-Sternberg cells in 47/223 HD cases (21%). There was found to be a tendency for higher Townsend scores (indicative of higher levels of material deprivation) in EBV-positive HD patients, but this association was not statistically significant. When various subgroups of patients from the study were examined separately the indication of higher Townsend scores in EBV-positive patients was found to be more marked for patients with mixed cellularity disease (P = 0.09) and for females (P = 0.03). The results of this study suggest that differences in the level of material deprivation are important in determining the likelihood of EBV-positive HD in the UK, particularly for certain subgroups of patients. It is not known what specific socioeconomic factors are responsible for these differences, although alterations in the timing or rate of primary EBV infection, or decline in the level of EBV-specific immunity, may be important. (Cancer Research UK)
Type: Article
Language: en
Keywords: Epstein-Barr virus
Hodgkin's Disease
West Midlands
Material deprivation
MeSH: Adolescent
Adult
Age Factors
Aged
Children
Child, Preschool
England
Female
Herpesviridae Infections
Herpesvirus 4, Human
Hodgkin's Disease
Humans
In Situ Hybridization
Infant
Infant, Newborn
Male
Middle Aged
Poverty
Sex Factors
Social Class
Tumor Virus Infections
ISSN: 0007-0920
1532-1827
Appears in Collections: Molecular Immunology Research Group

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