Vascular endothelial growth factor in astroglioma stem cell biology and response to therapy

2.50
Hdl Handle:
http://hdl.handle.net/2436/29814
Title:
Vascular endothelial growth factor in astroglioma stem cell biology and response to therapy
Authors:
Knizetova, Petra; Darling, John L.; Bartek, Jiri
Abstract:
Malignant astrogliomas are among the most aggressive, highly vascular and infiltrating tumours bearing a dismal prognosis, mainly due to their resistance to current radiation treatment and chemotherapy. Efforts to identify and target the mechanisms that underlie astroglioma resistance have recently focused on candidate cancer stem cells, their biological properties, interplay with their local microenvironment or 'niche', and their role in tumour progression and recurrence. Both paracrine and autocrine regulation of astroglioma cell behaviour by locally produced cytokines such as the vascular endothelial growth factor (VEGF) are emerging as key factors that determine astroglioma cell fate. Here, we review these recent rapid advances in astroglioma research, with emphasis on the significance of VEGF in astroglioma stem-like cell biology. Furthermore, we highlight the unique DNA damage checkpoint properties of the CD133-marker-positive astroglioma stem-like cells, discuss their potential involvement in astroglioma radioresistance, and consider the implications of this new knowledge for designing combinatorial, more efficient therapeutic strategies.
Citation:
Journal of Cellular and Molecular Medicine, 12(1): 111-125
Publisher:
Wiley InterScience
Journal:
Journal of Cellular and Molecular Medicine
Issue Date:
2008
URI:
http://hdl.handle.net/2436/29814
DOI:
10.1111/j.1582-4934.2007.00153.x
PubMed ID:
18031298
Additional Links:
http://www3.interscience.wiley.com/journal/119424038/abstract.x
Type:
Article
Language:
en
ISSN:
1582-1838
Appears in Collections:
Cancer Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorKnizetova, Petra-
dc.contributor.authorDarling, John L.-
dc.contributor.authorBartek, Jiri-
dc.date.accessioned2008-06-10T15:48:43Z-
dc.date.available2008-06-10T15:48:43Z-
dc.date.issued2008-
dc.identifier.citationJournal of Cellular and Molecular Medicine, 12(1): 111-125en
dc.identifier.issn1582-1838-
dc.identifier.pmid18031298-
dc.identifier.doi10.1111/j.1582-4934.2007.00153.x-
dc.identifier.urihttp://hdl.handle.net/2436/29814-
dc.description.abstractMalignant astrogliomas are among the most aggressive, highly vascular and infiltrating tumours bearing a dismal prognosis, mainly due to their resistance to current radiation treatment and chemotherapy. Efforts to identify and target the mechanisms that underlie astroglioma resistance have recently focused on candidate cancer stem cells, their biological properties, interplay with their local microenvironment or 'niche', and their role in tumour progression and recurrence. Both paracrine and autocrine regulation of astroglioma cell behaviour by locally produced cytokines such as the vascular endothelial growth factor (VEGF) are emerging as key factors that determine astroglioma cell fate. Here, we review these recent rapid advances in astroglioma research, with emphasis on the significance of VEGF in astroglioma stem-like cell biology. Furthermore, we highlight the unique DNA damage checkpoint properties of the CD133-marker-positive astroglioma stem-like cells, discuss their potential involvement in astroglioma radioresistance, and consider the implications of this new knowledge for designing combinatorial, more efficient therapeutic strategies.en
dc.language.isoenen
dc.publisherWiley InterScienceen
dc.relation.urlhttp://www3.interscience.wiley.com/journal/119424038/abstract.xen
dc.subjectOncologyen
dc.subjectCancer treatmenten
dc.subjectStem cell biologyen
dc.subjectVascular Endothelial Growth Factorsen
dc.subjectAstrogliomasen
dc.subjectMalignant tumoursen
dc.subjectBrain Tumoursen
dc.subjectChemotherapeutic targetsen
dc.subjectMolecular biologyen
dc.subjectResistanceen
dc.subjectRadiotherapyen
dc.subjectIonizing radiationen
dc.subjectEndothelial Growth Factors-
dc.titleVascular endothelial growth factor in astroglioma stem cell biology and response to therapyen
dc.typeArticleen
dc.identifier.journalJournal of Cellular and Molecular Medicineen

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