Synergistic antitumour effect of a combination of toremifene and interferon-alpha on ZR-75-1 human breast cancer cells: dependence on interferon-alpha subtype.

2.50
Hdl Handle:
http://hdl.handle.net/2436/29793
Title:
Synergistic antitumour effect of a combination of toremifene and interferon-alpha on ZR-75-1 human breast cancer cells: dependence on interferon-alpha subtype.
Authors:
Martin, Jan H.; Symonds, A.
Abstract:
We investigated the effect of toremifene, interferon-alpha2a, interferon-alpha2b and interferon-alpha2c, singly and in combination for their effect on the growth of ZR-75-1 human breast cancer cells. Median effect analysis was used to determine synergistic or additive effects. Anti-proliferative studies showed that the growth of ZR-75-1 cells was inhibited to a greater extent by combination treatment with toremifene plus interferon-alpha2a, resulting in a synergistic interaction (CI <1) for all concentrations tested. A combination of toremifene plus interferon-alpha2b resulted in a synergistic interaction (CI <1) for the two highest concentrations of toremifene (10(-6) and 10(-7) M) and an additive effect (CI approximately equal to 1) for the lower concentrations (10(-8) to 10(-10) M). When toremifene was combined with interferon-alpha2c no additive or synergistic interaction was determined.
Citation:
Oncology Reports, 9(2): 379-382
Publisher:
Spandidos Publications Ltd
Journal:
Oncology Reports
Issue Date:
2002
URI:
http://hdl.handle.net/2436/29793
PubMed ID:
11836612
Additional Links:
http://www.spandidos.com/or/
Type:
Article
Language:
en
ISSN:
1021-335X
Appears in Collections:
Cancer Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorMartin, Jan H.-
dc.contributor.authorSymonds, A.-
dc.date.accessioned2008-06-10T14:19:01Z-
dc.date.available2008-06-10T14:19:01Z-
dc.date.issued2002-
dc.identifier.citationOncology Reports, 9(2): 379-382en
dc.identifier.issn1021-335X-
dc.identifier.pmid11836612-
dc.identifier.urihttp://hdl.handle.net/2436/29793-
dc.description.abstractWe investigated the effect of toremifene, interferon-alpha2a, interferon-alpha2b and interferon-alpha2c, singly and in combination for their effect on the growth of ZR-75-1 human breast cancer cells. Median effect analysis was used to determine synergistic or additive effects. Anti-proliferative studies showed that the growth of ZR-75-1 cells was inhibited to a greater extent by combination treatment with toremifene plus interferon-alpha2a, resulting in a synergistic interaction (CI <1) for all concentrations tested. A combination of toremifene plus interferon-alpha2b resulted in a synergistic interaction (CI <1) for the two highest concentrations of toremifene (10(-6) and 10(-7) M) and an additive effect (CI approximately equal to 1) for the lower concentrations (10(-8) to 10(-10) M). When toremifene was combined with interferon-alpha2c no additive or synergistic interaction was determined.en
dc.language.isoenen
dc.publisherSpandidos Publications Ltden
dc.relation.urlhttp://www.spandidos.com/or/en
dc.subject.meshAntineoplastic Agents, Hormonalen
dc.subject.meshAntineoplastic Combined Chemotherapy Protocolsen
dc.subject.meshBreast Neoplasmsen
dc.subject.meshCell Divisionen
dc.subject.meshCell Lineen
dc.subject.meshDose-Response Relationship, Drugen
dc.subject.meshDrug Interactionsen
dc.subject.meshDrug Synergismen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshInterferon Alfa-2aen
dc.subject.meshInterferon Alfa-2ben
dc.subject.meshInterferon Alfa-2cen
dc.subject.meshToremifeneen
dc.subject.meshTumor Cells, Cultureden
dc.titleSynergistic antitumour effect of a combination of toremifene and interferon-alpha on ZR-75-1 human breast cancer cells: dependence on interferon-alpha subtype.en
dc.typeArticleen
dc.identifier.journalOncology Reportsen
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