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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Cancer Research Group > Synergistic antitumour effect of a combination of toremifene and interferon-alpha on ZR-75-1 human breast cancer cells: dependence on interferon-alpha subtype.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/29793
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Title: Synergistic antitumour effect of a combination of toremifene and interferon-alpha on ZR-75-1 human breast cancer cells: dependence on interferon-alpha subtype.
Authors: Martin, Jan H.
Symonds, A.
Citation: Oncology Reports, 9(2): 379-382
Publisher: Spandidos Publications Ltd
Journal: Oncology Reports
Issue Date: 2002
URI: http://hdl.handle.net/2436/29793
PubMed ID: 11836612
Additional Links: http://www.spandidos.com/or/
Abstract: We investigated the effect of toremifene, interferon-alpha2a, interferon-alpha2b and interferon-alpha2c, singly and in combination for their effect on the growth of ZR-75-1 human breast cancer cells. Median effect analysis was used to determine synergistic or additive effects. Anti-proliferative studies showed that the growth of ZR-75-1 cells was inhibited to a greater extent by combination treatment with toremifene plus interferon-alpha2a, resulting in a synergistic interaction (CI <1) for all concentrations tested. A combination of toremifene plus interferon-alpha2b resulted in a synergistic interaction (CI <1) for the two highest concentrations of toremifene (10(-6) and 10(-7) M) and an additive effect (CI approximately equal to 1) for the lower concentrations (10(-8) to 10(-10) M). When toremifene was combined with interferon-alpha2c no additive or synergistic interaction was determined.
Type: Article
Language: en
MeSH: Antineoplastic Agents, Hormonal
Antineoplastic Combined Chemotherapy Protocols
Breast Neoplasms
Cell Division
Cell Line
Dose-Response Relationship, Drug
Drug Interactions
Drug Synergism
Female
Humans
Interferon Alfa-2a
Interferon Alfa-2b
Interferon Alfa-2c
Toremifene
Tumor Cells, Cultured
ISSN: 1021-335X
Appears in Collections: Cancer Research Group

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