2.50
Hdl Handle:
http://hdl.handle.net/2436/29792
Title:
Picornavirus uncoating.
Authors:
Smyth, M.S.; Martin, Jan H.
Abstract:
Recently, much has been learned about the molecular mechanisms involved in the pathogenesis of picornaviruses. This has been accelerated by the solving of the crystal structures of many members of this virus family. However, one stage of the virus life cycle remains poorly understood: uncoating. How do these simple but efficient pathogens protect their RNA genomes with a stable protein shell and yet manage to uncoat this genome at precisely the right time during infection? The purpose of this article is to review the current state of knowledge and the most recent theories that attempt to answer this question. The review is based extensively on structural data but also makes reference to the wealth of biochemical information on the topic.
Citation:
Molecular Pathology, 55(4): 214-219
Publisher:
British Medical Association
Journal:
Molecular Pathology
Issue Date:
2002
URI:
http://hdl.handle.net/2436/29792
PubMed ID:
12147709
Additional Links:
http://direct.bl.uk/bld/PlaceOrder.do?UIN=117249347&ETOC=RN&from=searchengine
Type:
Article
Language:
en
ISSN:
1366-8714
Appears in Collections:
Cancer Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorSmyth, M.S.-
dc.contributor.authorMartin, Jan H.-
dc.date.accessioned2008-06-10T14:16:42Z-
dc.date.available2008-06-10T14:16:42Z-
dc.date.issued2002-
dc.identifier.citationMolecular Pathology, 55(4): 214-219en
dc.identifier.issn1366-8714-
dc.identifier.pmid12147709-
dc.identifier.urihttp://hdl.handle.net/2436/29792-
dc.description.abstractRecently, much has been learned about the molecular mechanisms involved in the pathogenesis of picornaviruses. This has been accelerated by the solving of the crystal structures of many members of this virus family. However, one stage of the virus life cycle remains poorly understood: uncoating. How do these simple but efficient pathogens protect their RNA genomes with a stable protein shell and yet manage to uncoat this genome at precisely the right time during infection? The purpose of this article is to review the current state of knowledge and the most recent theories that attempt to answer this question. The review is based extensively on structural data but also makes reference to the wealth of biochemical information on the topic.en
dc.language.isoenen
dc.publisherBritish Medical Associationen
dc.relation.urlhttp://direct.bl.uk/bld/PlaceOrder.do?UIN=117249347&ETOC=RN&from=searchengineen
dc.subjectPicornavirusesen
dc.subjectUncoatingen
dc.subjectX Ray Crystallographyen
dc.subjectAnimal viruses-
dc.subject.meshAnimalsen
dc.subject.meshCapsiden
dc.subject.meshCattleen
dc.subject.meshEnterovirus, Bovineen
dc.subject.meshHumansen
dc.subject.meshModels, Molecularen
dc.subject.meshPicornaviridaeen
dc.subject.meshVirulenceen
dc.titlePicornavirus uncoating.en
dc.typeArticleen
dc.identifier.journalMolecular Pathologyen

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