Wolverhampton Intellectual Repository and E-Theses >
Research Institutes >
Research Institute in Healthcare Science >
Cancer Research Group >
this identifier to cite or link
to this item:
|Title: ||Picornavirus uncoating.|
|Citation: ||Molecular Pathology, 55(4): 214-219|
|Publisher: ||British Medical Association|
|Journal: ||Molecular Pathology|
|Issue Date: ||2002 |
|PubMed ID: ||12147709|
|Additional Links: ||http://direct.bl.uk/bld/PlaceOrder.do?UIN=117249347&ETOC=RN&from=searchengine|
|Abstract: ||Recently, much has been learned about the molecular mechanisms involved in the pathogenesis of picornaviruses. This has been accelerated by the solving of the crystal structures of many members of this virus family. However, one stage of the virus life cycle remains poorly understood: uncoating. How do these simple but efficient pathogens protect their RNA genomes with a stable protein shell and yet manage to uncoat this genome at precisely the right time during infection? The purpose of this article is to review the current state of knowledge and the most recent theories that attempt to answer this question. The review is based extensively on structural data but also makes reference to the wealth of biochemical information on the topic.|
X Ray Crystallography
|Appears in Collections: ||Cancer Research Group|
|Files in This Item:|
There are no files associated with this item.
|Related articles on PubMed|
Picornavirus uncoating intermediate captured in atomic detail.
Ren J, Wang X, Hu Z, Gao Q, Sun Y, Li X, Porta C, Walter TS, Gilbert RJ, Zhao Y, Axford D, Williams M, McAuley K, Rowlands DJ, Yin W, Wang J, Stuart DI, Rao Z, Fry EE
|See all 87 articles|
All Items in WIRE are protected by copyright, with all rights reserved, unless otherwise indicated.