Down-regulation of nitric oxide production by droloxifene and toremifene in human breast cancer cells.

2.50
Hdl Handle:
http://hdl.handle.net/2436/29791
Title:
Down-regulation of nitric oxide production by droloxifene and toremifene in human breast cancer cells.
Authors:
Martin, Jan H.; Symonds, A.; Chohan, S.
Abstract:
We investigated the effect of tamoxifen, 4-OH tamoxifen, toremifene droloxifene, interferon-alpha2a, interferon-alpha2b and interferon-alpha2c, singly and in combination, for their effect on nitric oxide production by MCF-7 and ZR-75-1 human breast cancer cells. Tamoxifen and 4-OH tamoxifen singly had no effect on nitric oxide production by either cell line. However, treatment with droloxifene or toremifene significantly reduced nitric oxide production by both MCF-7 and ZR-75-1 human breast cancer cell lines. Combination treatment with anti-estrogens and interferon-alpha2a interferon-alpha2b or interferon-alpha2c had no synergistic or additive effect compared to each drug singly.
Citation:
Oncology Reports, 10 (4): 979-984
Publisher:
Spandidos Publications Ltd
Journal:
Oncology Reports
Issue Date:
2003
URI:
http://hdl.handle.net/2436/29791
PubMed ID:
12792756
Additional Links:
http://www.spandidos.com/or/; http://direct.bl.uk/bld/PlaceOrder.do?UIN=132226908&ETOC=RN&from=searchengine
Type:
Article
Language:
en
ISSN:
1021-335X
Appears in Collections:
Cancer Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorMartin, Jan H.-
dc.contributor.authorSymonds, A.-
dc.contributor.authorChohan, S.-
dc.date.accessioned2008-06-10T14:12:46Z-
dc.date.available2008-06-10T14:12:46Z-
dc.date.issued2003-
dc.identifier.citationOncology Reports, 10 (4): 979-984en
dc.identifier.issn1021-335X-
dc.identifier.pmid12792756-
dc.identifier.urihttp://hdl.handle.net/2436/29791-
dc.description.abstractWe investigated the effect of tamoxifen, 4-OH tamoxifen, toremifene droloxifene, interferon-alpha2a, interferon-alpha2b and interferon-alpha2c, singly and in combination, for their effect on nitric oxide production by MCF-7 and ZR-75-1 human breast cancer cells. Tamoxifen and 4-OH tamoxifen singly had no effect on nitric oxide production by either cell line. However, treatment with droloxifene or toremifene significantly reduced nitric oxide production by both MCF-7 and ZR-75-1 human breast cancer cell lines. Combination treatment with anti-estrogens and interferon-alpha2a interferon-alpha2b or interferon-alpha2c had no synergistic or additive effect compared to each drug singly.en
dc.language.isoenen
dc.publisherSpandidos Publications Ltden
dc.relation.urlhttp://www.spandidos.com/or/en
dc.relation.urlhttp://direct.bl.uk/bld/PlaceOrder.do?UIN=132226908&ETOC=RN&from=searchengine-
dc.subject.meshAntineoplastic Combined Chemotherapy Protocolsen
dc.subject.meshBreast Neoplasmsen
dc.subject.meshCell Divisionen
dc.subject.meshDose-Response Relationship, Drugen
dc.subject.meshDown-Regulationen
dc.subject.meshDrug Interactionsen
dc.subject.meshDrug Synergismen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshInterferon Alfa-2aen
dc.subject.meshInterferon Alfa-2ben
dc.subject.meshInterferon Alfa-2cen
dc.subject.meshNitric Oxideen
dc.subject.meshTamoxifenen
dc.subject.meshToremifeneen
dc.subject.meshTumor Cells, Cultureden
dc.titleDown-regulation of nitric oxide production by droloxifene and toremifene in human breast cancer cells.en
dc.typeArticleen
dc.identifier.journalOncology Reportsen
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