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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Cancer Research Group > Down-regulation of nitric oxide production by droloxifene and toremifene in human breast cancer cells.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/29791
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Title: Down-regulation of nitric oxide production by droloxifene and toremifene in human breast cancer cells.
Authors: Martin, Jan H.
Symonds, A.
Chohan, S.
Citation: Oncology Reports, 10 (4): 979-984
Publisher: Spandidos Publications Ltd
Journal: Oncology Reports
Issue Date: 2003
URI: http://hdl.handle.net/2436/29791
PubMed ID: 12792756
Additional Links: http://www.spandidos.com/or/
http://direct.bl.uk/bld/PlaceOrder.do?UIN=132226908&ETOC=RN&from=searchengine
Abstract: We investigated the effect of tamoxifen, 4-OH tamoxifen, toremifene droloxifene, interferon-alpha2a, interferon-alpha2b and interferon-alpha2c, singly and in combination, for their effect on nitric oxide production by MCF-7 and ZR-75-1 human breast cancer cells. Tamoxifen and 4-OH tamoxifen singly had no effect on nitric oxide production by either cell line. However, treatment with droloxifene or toremifene significantly reduced nitric oxide production by both MCF-7 and ZR-75-1 human breast cancer cell lines. Combination treatment with anti-estrogens and interferon-alpha2a interferon-alpha2b or interferon-alpha2c had no synergistic or additive effect compared to each drug singly.
Type: Article
Language: en
MeSH: Antineoplastic Combined Chemotherapy Protocols
Breast Neoplasms
Cell Division
Dose-Response Relationship, Drug
Down-Regulation
Drug Interactions
Drug Synergism
Female
Humans
Interferon Alfa-2a
Interferon Alfa-2b
Interferon Alfa-2c
Nitric Oxide
Tamoxifen
Toremifene
Tumor Cells, Cultured
ISSN: 1021-335X
Appears in Collections: Cancer Research Group

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