|Title: ||Down-regulation of nitric oxide production by droloxifene and toremifene in human breast cancer cells.|
|Citation: ||Oncology Reports, 10 (4): 979-984|
|Publisher: ||Spandidos Publications Ltd|
|Journal: ||Oncology Reports|
|Issue Date: ||2003 |
|PubMed ID: ||12792756|
|Additional Links: ||http://www.spandidos.com/or/|
|Abstract: ||We investigated the effect of tamoxifen, 4-OH tamoxifen, toremifene droloxifene, interferon-alpha2a, interferon-alpha2b and interferon-alpha2c, singly and in combination, for their effect on nitric oxide production by MCF-7 and ZR-75-1 human breast cancer cells. Tamoxifen and 4-OH tamoxifen singly had no effect on nitric oxide production by either cell line. However, treatment with droloxifene or toremifene significantly reduced nitric oxide production by both MCF-7 and ZR-75-1 human breast cancer cell lines. Combination treatment with anti-estrogens and interferon-alpha2a interferon-alpha2b or interferon-alpha2c had no synergistic or additive effect compared to each drug singly.|
|MeSH: ||Antineoplastic Combined Chemotherapy Protocols|
Dose-Response Relationship, Drug
Tumor Cells, Cultured
|Appears in Collections: ||Cancer Research Group|
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