Down-regulation of nitric oxide production by droloxifene and toremifene in human breast cancer cells.
Abstract
We investigated the effect of tamoxifen, 4-OH tamoxifen, toremifene droloxifene, interferon-alpha2a, interferon-alpha2b and interferon-alpha2c, singly and in combination, for their effect on nitric oxide production by MCF-7 and ZR-75-1 human breast cancer cells. Tamoxifen and 4-OH tamoxifen singly had no effect on nitric oxide production by either cell line. However, treatment with droloxifene or toremifene significantly reduced nitric oxide production by both MCF-7 and ZR-75-1 human breast cancer cell lines. Combination treatment with anti-estrogens and interferon-alpha2a interferon-alpha2b or interferon-alpha2c had no synergistic or additive effect compared to each drug singly.Citation
Oncology Reports, 10 (4): 979-984Publisher
Spandidos Publications LtdJournal
Oncology ReportsPubMed ID
12792756Additional Links
http://direct.bl.uk/bld/PlaceOrder.do?UIN=132226908&ETOC=RN&from=searchenginehttp://www.spandidos.com/or/Type
Journal articleLanguage
enISSN
1021-335XCollections
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