2.50
Hdl Handle:
http://hdl.handle.net/2436/29789
Title:
Human endogenous retroviruses: transposable elements with potential?
Authors:
Nelson, Paul N.; Hooley, Paul; Roden, Denise A.; Ejtehadi, H. Davari; Rylance, Paul; Warren, Phil; Martin, Jan H.; Murray, Paul G.
Abstract:
Human endogenous retroviruses (HERVs) are a significant component of a wider family of retroelements that constitute part of the human genome. These viruses, perhaps representative of previous exogenous retroviral infection, have been integrated and passed through successive generations within the germ line. The retention of HERVs and isolated elements, such as long-terminal repeats, could have the potential to harm. In this review we describe HERVs within the context of the family of known transposable elements and survey these viruses in terms of superantigens and molecular mimics. It is entirely possible that these mechanisms provide the potential for undesired immune responses.
Citation:
Clinical and Experimental Immunology, 138(1): 1-9
Publisher:
Wiley InterScience
Journal:
Clinical and Experimental Immunology
Issue Date:
2004
URI:
http://hdl.handle.net/2436/29789
DOI:
10.1111/j.1365-2249.2004.02592.x
PubMed ID:
15373898
Additional Links:
http://www3.interscience.wiley.com/journal/118749005/abstract
Type:
Article
Language:
en
ISSN:
0009-9104
Appears in Collections:
Cancer Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorNelson, Paul N.-
dc.contributor.authorHooley, Paul-
dc.contributor.authorRoden, Denise A.-
dc.contributor.authorEjtehadi, H. Davari-
dc.contributor.authorRylance, Paul-
dc.contributor.authorWarren, Phil-
dc.contributor.authorMartin, Jan H.-
dc.contributor.authorMurray, Paul G.-
dc.date.accessioned2008-06-10T13:58:28Z-
dc.date.available2008-06-10T13:58:28Z-
dc.date.issued2004-
dc.identifier.citationClinical and Experimental Immunology, 138(1): 1-9en
dc.identifier.issn0009-9104-
dc.identifier.pmid15373898-
dc.identifier.doi10.1111/j.1365-2249.2004.02592.x-
dc.identifier.urihttp://hdl.handle.net/2436/29789-
dc.description.abstractHuman endogenous retroviruses (HERVs) are a significant component of a wider family of retroelements that constitute part of the human genome. These viruses, perhaps representative of previous exogenous retroviral infection, have been integrated and passed through successive generations within the germ line. The retention of HERVs and isolated elements, such as long-terminal repeats, could have the potential to harm. In this review we describe HERVs within the context of the family of known transposable elements and survey these viruses in terms of superantigens and molecular mimics. It is entirely possible that these mechanisms provide the potential for undesired immune responses.en
dc.language.isoenen
dc.publisherWiley InterScienceen
dc.relation.urlhttp://www3.interscience.wiley.com/journal/118749005/abstracten
dc.subjectAutoimmunityen
dc.subjectHuman Endogenous Retrovirusesen
dc.subjectMolecular Mimicryen
dc.subjectTransposable Elementsen
dc.subject.meshDNA Transposable Elementsen
dc.subject.meshDNA, Viralen
dc.subject.meshEndogenous Retrovirusesen
dc.subject.meshEvolution, Molecularen
dc.subject.meshGenome, Humanen
dc.subject.meshHumansen
dc.subject.meshLong Interspersed Nucleotide Elementsen
dc.subject.meshRetroviridae Infectionsen
dc.subject.meshShort Interspersed Nucleotide Elementsen
dc.subject.meshSuperantigensen
dc.subject.meshTerminal Repeat Sequencesen
dc.subject.meshVirus Integrationen
dc.titleHuman endogenous retroviruses: transposable elements with potential?en
dc.typeArticleen
dc.identifier.journalClinical and Experimental Immunologyen

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