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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Cancer Research Group > Human endogenous retroviruses: transposable elements with potential?

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/29789
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Title: Human endogenous retroviruses: transposable elements with potential?
Authors: Nelson, Paul N.
Hooley, Paul
Roden, Denise A.
Ejtehadi, H. Davari
Rylance, Paul
Warren, Phil
Martin, Jan H.
Murray, Paul G.
Citation: Clinical and Experimental Immunology, 138(1): 1-9
Publisher: Wiley InterScience
Journal: Clinical and Experimental Immunology
Issue Date: 2004
URI: http://hdl.handle.net/2436/29789
DOI: 10.1111/j.1365-2249.2004.02592.x
PubMed ID: 15373898
Additional Links: http://www3.interscience.wiley.com/journal/118749005/abstract
Abstract: Human endogenous retroviruses (HERVs) are a significant component of a wider family of retroelements that constitute part of the human genome. These viruses, perhaps representative of previous exogenous retroviral infection, have been integrated and passed through successive generations within the germ line. The retention of HERVs and isolated elements, such as long-terminal repeats, could have the potential to harm. In this review we describe HERVs within the context of the family of known transposable elements and survey these viruses in terms of superantigens and molecular mimics. It is entirely possible that these mechanisms provide the potential for undesired immune responses.
Type: Article
Language: en
Keywords: Autoimmunity
Human Endogenous Retroviruses
Molecular Mimicry
Transposable Elements
MeSH: DNA Transposable Elements
DNA, Viral
Endogenous Retroviruses
Evolution, Molecular
Genome, Human
Humans
Long Interspersed Nucleotide Elements
Retroviridae Infections
Short Interspersed Nucleotide Elements
Superantigens
Terminal Repeat Sequences
Virus Integration
ISSN: 0009-9104
Appears in Collections: Cancer Research Group

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