|Title: ||Phytoestrogens: perpetrators or protectors?|
|Citation: ||Future Oncology, 3(3): 307-318|
|Publisher: ||Future Medicine Ltd|
|Journal: ||Future Oncology|
|Issue Date: ||2007 |
|PubMed ID: ||17547526|
|Additional Links: ||http://www.futuremedicine.com/doi/abs/10.2217/147966184.108.40.2067|
|Abstract: ||Phytoestrogens are estrogen-like substances produced by plants that account for some of the constituents present in vegetation that may be responsible for the health benefits of a diet rich in fruit and vegetables. Phytoestrogens have a plethora of different actions that they are capable of exerting on cellular metabolism. This review will focus on some of the major non-estrogen receptor-mediated cellular effects used by phytoestrogens and will draw attention to the fact that while they may have a number of beneficial effects, particularly in offering a protective effect against some hormone-dependent cancers, such as breast and prostate cancer, they may also have possible unfavorable effects by interfering with the functioning of normal cellular activities such as receptor-mediated signal transduction and DNA replication, as well as being genotoxic, mutagenic and promoting the proliferation of some cancer cells.|
Nonestrogen receptor mechanisms
|Appears in Collections: ||Cancer Research Group|
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