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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Cancer Research Group > Phytoestrogens: perpetrators or protectors?

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/29765
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Title: Phytoestrogens: perpetrators or protectors?
Authors: Martin, Jan H.
Crotty, Stephen
Nelson, Paul N.
Citation: Future Oncology, 3(3): 307-318
Publisher: Future Medicine Ltd
Journal: Future Oncology
Issue Date: 2007
URI: http://hdl.handle.net/2436/29765
DOI: 10.2217/14796694.3.3.307
PubMed ID: 17547526
Additional Links: http://www.futuremedicine.com/doi/abs/10.2217/14796694.3.3.307
Abstract: Phytoestrogens are estrogen-like substances produced by plants that account for some of the constituents present in vegetation that may be responsible for the health benefits of a diet rich in fruit and vegetables. Phytoestrogens have a plethora of different actions that they are capable of exerting on cellular metabolism. This review will focus on some of the major non-estrogen receptor-mediated cellular effects used by phytoestrogens and will draw attention to the fact that while they may have a number of beneficial effects, particularly in offering a protective effect against some hormone-dependent cancers, such as breast and prostate cancer, they may also have possible unfavorable effects by interfering with the functioning of normal cellular activities such as receptor-mediated signal transduction and DNA replication, as well as being genotoxic, mutagenic and promoting the proliferation of some cancer cells.
Type: Article
Language: en
Keywords: Cancer
Diet
Nonestrogen receptor mechanisms
Phytoestrogens
MeSH: Humans
Neoplasms
Phytoestrogens
Phytotherapy
ISSN: 1479-6694
Appears in Collections: Cancer Research Group

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