Vitamin E correlates inversely with non-transferrin-bound iron in sickle cell disease.
Authors
Marwah, S.S.Wheelwright, D.
Blann, A.D.
Rea, C.
Beresford, R.
Phillips, Jonathan D.
Wright, J.
Bareford, D.
Issue Date
2001
Metadata
Show full item recordAbstract
Decreased serum vitamin E levels are found in homozygous sickle cell disease (SCD). Excessive transfusions may lead high non-transferrin-bound iron (NTBI). Hypothesizing a relationship between the two, vitamin E (measured using high performance liquid chromatography) was significantly lower in 30 SCD patients than in 30 age-/sex-matched controls (P < 0.001), but NTBI (bleomycin assay) was higher (P < 0.001). Vitamin E was lower in 10 transfused patients than in 20 non-transfused patients (P < 0.001) with a significant inverse correlation between the NTBI and vitamin E (r = -0.58, P < 0.001). NTBI associated with iron overload in SCD may increase the potential for oxidative damage and low vitamin E activity may compound this effect.Citation
British Journal of Haematology, 114(4): 917-919Publisher
Wiley InterScienceJournal
British Journal of HaematologyPubMed ID
11564086Additional Links
http://www.ingentaconnect.com/content/bsc/bjh/2001/00000114/00000004/art00028http://www3.interscience.wiley.com/journal/121374046/abstractType
Journal articleLanguage
enISSN
0007-1048ae974a485f413a2113503eed53cd6c53
10.1046/j.1365-2141.2001.03018.x