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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Diabetes, Physiology and Molecular Medicine Research Group > Vitamin E correlates inversely with non-transferrin-bound iron in sickle cell disease.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/29475
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Title: Vitamin E correlates inversely with non-transferrin-bound iron in sickle cell disease.
Authors: Marwah, S.S.
Wheelwright, D.
Blann, A.D.
Rea, C.
Beresford, R.
Phillips, Jonathan D.
Wright, J.
Bareford, D.
Citation: British Journal of Haematology, 114(4): 917-919
Publisher: Wiley InterScience
Journal: British Journal of Haematology
Issue Date: 2001
URI: http://hdl.handle.net/2436/29475
DOI: 10.1046/j.1365-2141.2001.03018.x
PubMed ID: 11564086
Additional Links: http://www3.interscience.wiley.com/journal/121374046/abstract
http://www.ingentaconnect.com/content/bsc/bjh/2001/00000114/00000004/art00028
Abstract: Decreased serum vitamin E levels are found in homozygous sickle cell disease (SCD). Excessive transfusions may lead high non-transferrin-bound iron (NTBI). Hypothesizing a relationship between the two, vitamin E (measured using high performance liquid chromatography) was significantly lower in 30 SCD patients than in 30 age-/sex-matched controls (P < 0.001), but NTBI (bleomycin assay) was higher (P < 0.001). Vitamin E was lower in 10 transfused patients than in 20 non-transfused patients (P < 0.001) with a significant inverse correlation between the NTBI and vitamin E (r = -0.58, P < 0.001). NTBI associated with iron overload in SCD may increase the potential for oxidative damage and low vitamin E activity may compound this effect.
Type: Article
Language: en
Keywords: Sickle cell disease
Antioxidant activity
Vitamin E
NTBI
MeSH: Adult
Anemia, Sickle Cell
Antioxidants
Blood Transfusion
Case-Control Studies
Chromatography, High Pressure Liquid
Female
Humans
Iron
Male
Statistics, Nonparametric
Transferrin
Vitamin E
ISSN: 0007-1048
Appears in Collections: Diabetes, Physiology and Molecular Medicine Research Group

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