2.50
Hdl Handle:
http://hdl.handle.net/2436/29475
Title:
Vitamin E correlates inversely with non-transferrin-bound iron in sickle cell disease.
Authors:
Marwah, S.S.; Wheelwright, D.; Blann, A.D.; Rea, C.; Beresford, R.; Phillips, Jonathan D.; Wright, J.; Bareford, D.
Abstract:
Decreased serum vitamin E levels are found in homozygous sickle cell disease (SCD). Excessive transfusions may lead high non-transferrin-bound iron (NTBI). Hypothesizing a relationship between the two, vitamin E (measured using high performance liquid chromatography) was significantly lower in 30 SCD patients than in 30 age-/sex-matched controls (P < 0.001), but NTBI (bleomycin assay) was higher (P < 0.001). Vitamin E was lower in 10 transfused patients than in 20 non-transfused patients (P < 0.001) with a significant inverse correlation between the NTBI and vitamin E (r = -0.58, P < 0.001). NTBI associated with iron overload in SCD may increase the potential for oxidative damage and low vitamin E activity may compound this effect.
Citation:
British Journal of Haematology, 114(4): 917-919
Publisher:
Wiley InterScience
Journal:
British Journal of Haematology
Issue Date:
2001
URI:
http://hdl.handle.net/2436/29475
DOI:
10.1046/j.1365-2141.2001.03018.x
PubMed ID:
11564086
Additional Links:
http://www3.interscience.wiley.com/journal/121374046/abstract; http://www.ingentaconnect.com/content/bsc/bjh/2001/00000114/00000004/art00028
Type:
Article
Language:
en
ISSN:
0007-1048
Appears in Collections:
Diabetes, Physiology and Molecular Medicine Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorMarwah, S.S.-
dc.contributor.authorWheelwright, D.-
dc.contributor.authorBlann, A.D.-
dc.contributor.authorRea, C.-
dc.contributor.authorBeresford, R.-
dc.contributor.authorPhillips, Jonathan D.-
dc.contributor.authorWright, J.-
dc.contributor.authorBareford, D.-
dc.date.accessioned2008-06-04T11:21:11Z-
dc.date.available2008-06-04T11:21:11Z-
dc.date.issued2001-
dc.identifier.citationBritish Journal of Haematology, 114(4): 917-919en
dc.identifier.issn0007-1048-
dc.identifier.pmid11564086-
dc.identifier.doi10.1046/j.1365-2141.2001.03018.x-
dc.identifier.urihttp://hdl.handle.net/2436/29475-
dc.description.abstractDecreased serum vitamin E levels are found in homozygous sickle cell disease (SCD). Excessive transfusions may lead high non-transferrin-bound iron (NTBI). Hypothesizing a relationship between the two, vitamin E (measured using high performance liquid chromatography) was significantly lower in 30 SCD patients than in 30 age-/sex-matched controls (P < 0.001), but NTBI (bleomycin assay) was higher (P < 0.001). Vitamin E was lower in 10 transfused patients than in 20 non-transfused patients (P < 0.001) with a significant inverse correlation between the NTBI and vitamin E (r = -0.58, P < 0.001). NTBI associated with iron overload in SCD may increase the potential for oxidative damage and low vitamin E activity may compound this effect.en
dc.language.isoenen
dc.publisherWiley InterScienceen
dc.relation.urlhttp://www3.interscience.wiley.com/journal/121374046/abstracten
dc.relation.urlhttp://www.ingentaconnect.com/content/bsc/bjh/2001/00000114/00000004/art00028-
dc.subjectSickle cell diseaseen
dc.subjectAntioxidant activityen
dc.subjectVitamin Een
dc.subjectNTBIen
dc.subject.meshAdulten
dc.subject.meshAnemia, Sickle Cellen
dc.subject.meshAntioxidantsen
dc.subject.meshBlood Transfusionen
dc.subject.meshCase-Control Studiesen
dc.subject.meshChromatography, High Pressure Liquiden
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshIronen
dc.subject.meshMaleen
dc.subject.meshStatistics, Nonparametricen
dc.subject.meshTransferrinen
dc.subject.meshVitamin Een
dc.titleVitamin E correlates inversely with non-transferrin-bound iron in sickle cell disease.en
dc.typeArticleen
dc.identifier.journalBritish Journal of Haematologyen

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