|Title: ||Vitamin E correlates inversely with non-transferrin-bound iron in sickle cell disease.|
|Citation: ||British Journal of Haematology, 114(4): 917-919|
|Publisher: ||Wiley InterScience|
|Journal: ||British Journal of Haematology|
|Issue Date: ||2001 |
|PubMed ID: ||11564086|
|Additional Links: ||http://www3.interscience.wiley.com/journal/121374046/abstract|
|Abstract: ||Decreased serum vitamin E levels are found in homozygous sickle cell disease (SCD). Excessive transfusions may lead high non-transferrin-bound iron (NTBI). Hypothesizing a relationship between the two, vitamin E (measured using high performance liquid chromatography) was significantly lower in 30 SCD patients than in 30 age-/sex-matched controls (P < 0.001), but NTBI (bleomycin assay) was higher (P < 0.001). Vitamin E was lower in 10 transfused patients than in 20 non-transfused patients (P < 0.001) with a significant inverse correlation between the NTBI and vitamin E (r = -0.58, P < 0.001). NTBI associated with iron overload in SCD may increase the potential for oxidative damage and low vitamin E activity may compound this effect.|
|Keywords: ||Sickle cell disease|
Anemia, Sickle Cell
Chromatography, High Pressure Liquid
|Appears in Collections: ||Diabetes, Physiology and Molecular Medicine Research Group|
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