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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Diabetes, Physiology and Molecular Medicine Research Group > Increased non-transferrin bound iron in plasma-depleted SAG-M red blood cell units.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/29473
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Title: Increased non-transferrin bound iron in plasma-depleted SAG-M red blood cell units.
Authors: Marwah, S.S.
Blann, A.D.
Harrison, P.
Lumley, M.A.
Wright, J.
McDowell, J.
Phillips, Jonathan D.
Rea, C.
Bareford, D.
Citation: Vox Sanguinis, 82(3): 122-126
Publisher: Wiley InterScience
Journal: Vox Sanguinis
Issue Date: 2002
URI: http://hdl.handle.net/2436/29473
DOI: 10.1046/j.1423-0410.2002.00153.x
PubMed ID: 11952985
Additional Links: http://www3.interscience.wiley.com/journal/118912470/abstract
http://www.ingentaconnect.com/content/bsc/vox/2002/00000082/00000003/art00003
http://direct.bl.uk/bld/PlaceOrder.do?UIN=110927228&ETOC=RN&from=searchengine
Abstract: BACKGROUND AND OBJECTIVES: Non-transferrin bound iron (NTBI) is associated with increased morbidity in a number of transfusion-dependent disease states such as the severe haemoglobinopathies. We hypothesized that this may be related to excess NTBI present in plasma-depleted red blood cell units that are free of clear haemolysis. MATERIALS AND METHODS: The level of NTBI was determined using the bleomycin assay in samples from 20 stored plasma-depleted red cell units, at approximate 5-day intervals up to day 33 after donation. Forty units of fresh-frozen plasma (FFP) and 40 units of platelet concentrates were used as negative controls, and samples from 12 units of FFP were also serially assessed. RESULTS: Median [interquartile range (IQR)] NTBI was 0 microm (0-0.35) in samples taken from units 3-10 days after donation. Thereafter, the levels of NTBI increased, becoming significant (median 3.05; IQR: 0.05-6.7 microm) 17-22 days after donation. After 30 days, NTBI was detectable in all red cell units. NTBI was undetectable in platelet concentrates and FFP. CONCLUSIONS: Increased levels of NTBI become detectable 17-22 days after donation and increase further with storage time. This excess NTBI may promote bacterial infection in iron-loaded individuals.
Type: Article
Language: en
Keywords: Bacterial contamination
Fresh-frozen plasma
Blood Transfusion
Nontransferrin bound iron (NTBI)
Platelets
SAG-M
MeSH: Bacterial Infections
Blood Preservation
Erythrocyte Transfusion
Erythrocytes
Humans
Iron Overload
Plasma Substitutes
Time Factors
Transferrin
ISSN: 0042-9007
Appears in Collections: Diabetes, Physiology and Molecular Medicine Research Group

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