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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Food Biology, Medical Microbiology and Disinfection Research Group > A pilot study to determine the effectiveness of garlic oil capsules in the treatment of dyspeptic patients with Helicobacter pylori.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/29464
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Title: A pilot study to determine the effectiveness of garlic oil capsules in the treatment of dyspeptic patients with Helicobacter pylori.
Authors: McNulty, Cliodna A. M.
Wilson, Melanie P.
Havinga, Wouter
Johnston, Belinda
O'Gara, Elizabeth A.
Maslin, David J.
Citation: Helicobacter, 6(3): 249-253
Publisher: Wiley InterScience
Journal: Helicobacter
Issue Date: 2001
URI: http://hdl.handle.net/2436/29464
DOI: 10.1046/j.1523-5378.2001.00036.x
PubMed ID: 11683929
Additional Links: http://www3.interscience.wiley.com/journal/120846013/abstract
Abstract: BACKGROUND: Resistance of Helicobacter pylori to clarithromycin and metronidazole is now found worldwide. Steam-distilled garlic oil has in vitro activity against H. pylori and may be a useful alternative treatment strategy. MATERIALS AND METHODS: In this pilot study dyspeptic patients with positive serology for H. pylori confirmed by 13C urea breath test (UBT), at 0 and 2 weeks, were enrolled. Treatment consisted of one 4 mg garlic oil capsule with a meal four times per day for 14 days. H. pylori eradication was defined as a negative UBT at both follow-up appointments. Suppression was defined as a 50% fall in 13C excess between baseline and follow-up 1. RESULTS: Five patients completed the study. There was no evidence of either eradication or suppression of H. pylori or symptom improvement whilst taking garlic oil. CONCLUSION: These negative results show that, within the gastric milieu, garlic oil at this dose does not inhibit H. pylori. A higher dose administered for a longer time-period may be effective. Antibiotics are usually combined with a proton-pump inhibitor or bismuth salt, as the only antibiotic with any in vivo activity against H. pylori in monotherapy is clarithromycin. A proton pump inhibitor raises gastric pH and, by increasing bacterial division, may increase the in vivo activity of garlic oil. This may be worth pursuing in a future trial.
Type: Article
Language: en
Keywords: Treatment
Resistance
MeSH: Adult
Aged
Allyl Compounds
Breath Tests
Drug Administration Schedule
Dyspepsia
Forecasting
Garlic
Helicobacter Infections
Helicobacter pylori
Humans
Middle Aged
Phytotherapy
Pilot Projects
Sulfides
ISSN: 1083-4389
Appears in Collections: Food Biology, Medical Microbiology and Disinfection Research Group

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