Role of sexual behavior in the acquisition of asymptomatic Epstein-Barr virus infection: a longitudinal study.

2.50
Hdl Handle:
http://hdl.handle.net/2436/29460
Title:
Role of sexual behavior in the acquisition of asymptomatic Epstein-Barr virus infection: a longitudinal study.
Authors:
Woodman, Ciaran; Collins, Stuart; Vavrusova, Nicol; Rao, Ankit; Middeldorp, Jaap; Kolar, Zdenek; Kumari, Angela; Nelson, Paul N.; Young, Lawrence S.; Murray, Paul G.
Abstract:
BACKGROUND: The natural history of Epstein-Barr virus (EBV) infection is poorly defined. We report the prevalence and subsequent incidence of EBV infection in a cohort of sexually active young women and explore the social and sexual determinants of incident infections. METHODS: The study population was drawn from a cohort of young women, who were recruited for a longitudinal study of risk factors for early cervical neoplasia. A case-control analysis, nested within the cohort of 45 women for whom the first EBV sample tested was EBV-negative and who had further follow-up, was undertaken. EBV serostatus was determined in serum with a synthetic peptide-based enzyme-linked immunosorbent assay; EBV DNA was measured in cervical smears with the use of quantitative polymerase chain reaction. RESULTS: Of 1023 women 15-19 years of age included in this analysis, 978 (95.6%) tested positive for antibodies to EBV in their first serum sample. Of 45 women who tested negative, 22 subsequently acquired an asymptomatic EBV infection; the median time to seroconversion was 25 months (range, 1-60 months), and the median age at seroconversion was 18 years (range, 16-21 years). The risk of seroconversion increased with increasing number of sexual partners [compared with 1 partner, odds ratio (OR) was 1.28 for 2 partners and 2.23 for 3 or more; chiTREND 5.02; df 1; P < 0.05] and was greatest when a new sexual partner had been acquired in the 2 years before seroconversion (OR 4.78; chi 4.62; df 1; P < 0.05). EBV DNA was detected in 9 of 14 women who seroconverted and who also provided cervical samples. CONCLUSIONS: In susceptible young women, the acquisition of EBV infection is associated with their sexual behavior.
Citation:
Pediatric Infectious Diseases Journal, 24 (6): 498-502
Publisher:
Lippincott Williams & Wilkins
Journal:
Pediatric Infectious Diseases Journal
Issue Date:
2005
URI:
http://hdl.handle.net/2436/29460
DOI:
10.1097/01.inf.0000164709.40358.b6
PubMed ID:
15933558
Additional Links:
http://www.pidj.org/pt/re/pidj/abstract.00006454-200506000-00005.htm;jsessionid=LGyXvg71L5xxkxsKVrR9phZPJ7J86QMnmGGP2hmh7C85ppMBGTfz!-1610132471!181195628!8091!-1
Type:
Article
Language:
en
ISSN:
0891-3668
Appears in Collections:
Molecular Immunology Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorWoodman, Ciaran-
dc.contributor.authorCollins, Stuart-
dc.contributor.authorVavrusova, Nicol-
dc.contributor.authorRao, Ankit-
dc.contributor.authorMiddeldorp, Jaap-
dc.contributor.authorKolar, Zdenek-
dc.contributor.authorKumari, Angela-
dc.contributor.authorNelson, Paul N.-
dc.contributor.authorYoung, Lawrence S.-
dc.contributor.authorMurray, Paul G.-
dc.date.accessioned2008-06-04T10:07:04Z-
dc.date.available2008-06-04T10:07:04Z-
dc.date.issued2005-
dc.identifier.citationPediatric Infectious Diseases Journal, 24 (6): 498-502en
dc.identifier.issn0891-3668-
dc.identifier.pmid15933558-
dc.identifier.doi10.1097/01.inf.0000164709.40358.b6-
dc.identifier.urihttp://hdl.handle.net/2436/29460-
dc.description.abstractBACKGROUND: The natural history of Epstein-Barr virus (EBV) infection is poorly defined. We report the prevalence and subsequent incidence of EBV infection in a cohort of sexually active young women and explore the social and sexual determinants of incident infections. METHODS: The study population was drawn from a cohort of young women, who were recruited for a longitudinal study of risk factors for early cervical neoplasia. A case-control analysis, nested within the cohort of 45 women for whom the first EBV sample tested was EBV-negative and who had further follow-up, was undertaken. EBV serostatus was determined in serum with a synthetic peptide-based enzyme-linked immunosorbent assay; EBV DNA was measured in cervical smears with the use of quantitative polymerase chain reaction. RESULTS: Of 1023 women 15-19 years of age included in this analysis, 978 (95.6%) tested positive for antibodies to EBV in their first serum sample. Of 45 women who tested negative, 22 subsequently acquired an asymptomatic EBV infection; the median time to seroconversion was 25 months (range, 1-60 months), and the median age at seroconversion was 18 years (range, 16-21 years). The risk of seroconversion increased with increasing number of sexual partners [compared with 1 partner, odds ratio (OR) was 1.28 for 2 partners and 2.23 for 3 or more; chiTREND 5.02; df 1; P < 0.05] and was greatest when a new sexual partner had been acquired in the 2 years before seroconversion (OR 4.78; chi 4.62; df 1; P < 0.05). EBV DNA was detected in 9 of 14 women who seroconverted and who also provided cervical samples. CONCLUSIONS: In susceptible young women, the acquisition of EBV infection is associated with their sexual behavior.en
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen
dc.relation.urlhttp://www.pidj.org/pt/re/pidj/abstract.00006454-200506000-00005.htm;jsessionid=LGyXvg71L5xxkxsKVrR9phZPJ7J86QMnmGGP2hmh7C85ppMBGTfz!-1610132471!181195628!8091!-1en
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAntibodies, Viralen
dc.subject.meshCase-Control Studiesen
dc.subject.meshCohort Studiesen
dc.subject.meshDNA, Viralen
dc.subject.meshEpstein-Barr Virus Infectionsen
dc.subject.meshFemaleen
dc.subject.meshHerpesvirus 4, Humanen
dc.subject.meshHumansen
dc.subject.meshLongitudinal Studiesen
dc.subject.meshPrevalenceen
dc.subject.meshRisk Factorsen
dc.subject.meshSexual Behavioren
dc.subject.meshSexual Partnersen
dc.subject.meshSexually Transmitted Diseases, Viralen
dc.titleRole of sexual behavior in the acquisition of asymptomatic Epstein-Barr virus infection: a longitudinal study.en
dc.typeArticleen
dc.identifier.journalPediatric Infectious Diseases Journalen

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