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Title: Role of sexual behavior in the acquisition of asymptomatic Epstein-Barr virus infection: a longitudinal study.
Authors: Woodman, Ciaran
Collins, Stuart
Vavrusova, Nicol
Rao, Ankit
Middeldorp, Jaap
Kolar, Zdenek
Kumari, Angela
Nelson, Paul N.
Young, Lawrence S.
Murray, Paul G.
Citation: Pediatric Infectious Diseases Journal, 24 (6): 498-502
Publisher: Lippincott Williams & Wilkins
Journal: Pediatric Infectious Diseases Journal
Issue Date: 2005
DOI: 10.1097/01.inf.0000164709.40358.b6
PubMed ID: 15933558
Additional Links:;jsessionid=LGyXvg71L5xxkxsKVrR9phZPJ7J86QMnmGGP2hmh7C85ppMBGTfz!-1610132471!181195628!8091!-1
Abstract: BACKGROUND: The natural history of Epstein-Barr virus (EBV) infection is poorly defined. We report the prevalence and subsequent incidence of EBV infection in a cohort of sexually active young women and explore the social and sexual determinants of incident infections. METHODS: The study population was drawn from a cohort of young women, who were recruited for a longitudinal study of risk factors for early cervical neoplasia. A case-control analysis, nested within the cohort of 45 women for whom the first EBV sample tested was EBV-negative and who had further follow-up, was undertaken. EBV serostatus was determined in serum with a synthetic peptide-based enzyme-linked immunosorbent assay; EBV DNA was measured in cervical smears with the use of quantitative polymerase chain reaction. RESULTS: Of 1023 women 15-19 years of age included in this analysis, 978 (95.6%) tested positive for antibodies to EBV in their first serum sample. Of 45 women who tested negative, 22 subsequently acquired an asymptomatic EBV infection; the median time to seroconversion was 25 months (range, 1-60 months), and the median age at seroconversion was 18 years (range, 16-21 years). The risk of seroconversion increased with increasing number of sexual partners [compared with 1 partner, odds ratio (OR) was 1.28 for 2 partners and 2.23 for 3 or more; chiTREND 5.02; df 1; P < 0.05] and was greatest when a new sexual partner had been acquired in the 2 years before seroconversion (OR 4.78; chi 4.62; df 1; P < 0.05). EBV DNA was detected in 9 of 14 women who seroconverted and who also provided cervical samples. CONCLUSIONS: In susceptible young women, the acquisition of EBV infection is associated with their sexual behavior.
Type: Article
Language: en
MeSH: Adolescent
Antibodies, Viral
Case-Control Studies
Cohort Studies
DNA, Viral
Epstein-Barr Virus Infections
Herpesvirus 4, Human
Longitudinal Studies
Risk Factors
Sexual Behavior
Sexual Partners
Sexually Transmitted Diseases, Viral
ISSN: 0891-3668
Appears in Collections: Molecular Immunology Research Group

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