University of Wolverhampton
Browse
Collection All
bullet
bullet
bullet
bullet
Listed communities
bullet
bullet
bullet
bullet
bullet
bullet
bullet
bullet
bullet
bullet
bullet
bullet
bullet

Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Molecular Immunology Research Group  > South Asian ethnicity and material deprivation increase the risk of Epstein-Barr virus infection in childhood Hodgkin's disease.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/29447
    Del.icio.us     LinkedIn     Citeulike     Connotea     Facebook     Stumble it!



Title: South Asian ethnicity and material deprivation increase the risk of Epstein-Barr virus infection in childhood Hodgkin's disease.
Authors: Flavell, K.J.
Biddulph, J.P.
Powell, J.E.
Parkes, S.E.
Redfern, D.
Weinreb, M.
Nelson, Paul N.
Mann, J.R.
Young, Lawrence S.
Murray, Paul G.
Citation: British Journal of Cancer, 85 (3): 350-6
Publisher: Nature Publishing Group
Journal: British Journal of Cancer
Issue Date: 2001
URI: http://hdl.handle.net/2436/29447
DOI: 10.1054/bjoc.2001.1872
PubMed ID: 11487264
Additional Links: http://www.nature.com/bjc/journal/v85/n3/abs/6691872a.html
Abstract: In order to further define the factors associated with the observed variations in the Epstein-Barr virus-positive rate in childhood Hodgkin's disease, we have studied the effect of material deprivation (measured by the Townsend score) and ethnic origin on the frequency of Epstein-Barr virus-positivity in 55 cases of childhood Hodgkin's disease, diagnosed between 1981 and 1999, from a multi-ethnic region of the United Kingdom. Epstein-Barr virus status was determined by immunohistochemistry for the Epstein-Barr virus-encoded latent membrane protein-1. 62% of cases were Epstein-Barr virus-positive. Ethnic group was the strongest predictor of Epstein-Barr virus-positivity, with South Asians having a more than 20-fold risk of being Epstein-Barr virus-positive compared with non-South Asians. An increased risk was still present after adjusting for deprivation. Townsend scores were significantly higher (indicating more deprivation) in the Epstein-Barr virus-positive group, particularly in males. The relative risk of Epstein-Barr virus-positivity showed a gradient with increasing Townsend score; the risk being 7-times higher in the most deprived quartile compared with the least deprived group. Although the association between Townsend score and Epstein-Barr virus-positivity was reduced after adjusting for ethnic group, the risk of Epstein-Barr virus-positivity was still 3-times higher in the most deprived compared with the least deprived quartile. In addition, cases having 2 or more siblings were 5-times as likely to be Epstein-Barr virus-positive as those from smaller families. These results provide the first evidence of a strong association between Epstein-Barr virus-positive Hodgkin's disease and South Asian children from the United Kingdom. In addition, deprivation may increase the likelihood of Epstein-Barr virus-positive disease independently of ethnicity.
Type: Article
Language: en
Keywords: Hodgkin's Disease
Epstein-Barr virus
Ethnicity
Childhood
Material deprivation
MeSH: Adolescent
Adult
Antigens, Viral
Asia
Children
Child, Preschool
Economics
Epstein-Barr Virus Infections
Female
Humans
Immunohistochemistry
In Situ Hybridization
Incidence
Infant
Infant, Newborn
Male
Middle Aged
Risk Factors
Viral Matrix Proteins
ISSN: 0007-0920
Appears in Collections: Molecular Immunology Research Group

Files in This Item:

There are no files associated with this item.



Related articles on PubMed
bullet
Longer failure-free survival interval of Epstein-Barr virus-associated classical Hodgkin's lymphoma: a single-institution study.
Krugmann J, Tzankov A, Gschwendtner A, Fischhofer M, Greil R, Fend F, Dirnhofer S
2003 Jun
bullet
[Association of Hodgkin lymphoma with Epstein-Barr virus in Hungary].
Keresztes K, Bessenyei B, Szöllosi Z, Beck Z, Miltényi Z, Nemes Z, Oláh E, Illés A
2005 Jul 24
bullet
Effect of material deprivation on Epstein-Barr virus infection in Hodgkin's disease in the West Midlands.
Flavell K, Constandinou C, Lowe D, Scott K, Newey C, Evans D, Dutton A, Simmons S, Smith R, Crocker J, Young LS, Murray P
1999 May
bullet
[Epstein-Barr virus in Hodgkin's disease: the example of central Tunisia].
Korbi S, Trimeche M, Sriha B, Yacoubi MT, Hmissa S, Mokni M, Delvenne P, Boniver J, Rammeh S
2002 Apr
bullet
See all 198 articles

All Items in WIRE are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Fairtrade - Guarantees a better deal for Third World Producers

University of Wolverhampton, Wulfruna Street, Wolverhampton, WV1 1LY

Course enquiries: 0800 953 3222, General enquiries: 01902 321000,
Email: enquiries@wlv.ac.uk | Freedom of Information | Disclaimer and copyright | Website feedback | The University as a charity

OR Logo Powered by Open Repository | Cookies