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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Molecular Immunology Research Group  > Interleukin 6 expression by Hodgkin/Reed-Sternberg cells is associated with the presence of 'B' symptoms and failure to achieve complete remission in patients with advanced Hodgkin's disease.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/29446
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Title: Interleukin 6 expression by Hodgkin/Reed-Sternberg cells is associated with the presence of 'B' symptoms and failure to achieve complete remission in patients with advanced Hodgkin's disease.
Authors: Reynolds, Gary
Billingham, Lucinda
Gray, Laura
Flavell, Joanne R.
Najafipour, Sohrab
Crocker, John
Nelson, Paul N.
Young, Lawrence S.
Murray, Paul G.
Citation: British Journal of Haematology, 118 (1): 195-201
Publisher: Blackwell Synergy
Journal: British Journal of Haematology
Issue Date: 2002
URI: http://hdl.handle.net/2436/29446
DOI: 10.1046/j.1365-2141.2002.03575.x
PubMed ID: 12100148
Additional Links: http://www.ingentaconnect.com/content/bsc/bjh/2002/00000118/00000001/art00027?token=0051107f39412f415d487725737b742b2f423f5142253048296a7c2849266d656cc66329cb2bf6951
Abstract: Interleukin 6 (IL-6) is a potent immunomodulatory cytokine that has pathogenic and prognostic significance in a number of disorders. Previous studies in Hodgkin's disease (HD) have demonstrated the association between elevated serum levels of IL-6 and unfavourable prognosis, including advanced stage and the presence of 'B' symptoms and with reduced survival. Although IL-6 expression has been demonstrated in both the malignant Hodgkin/Reed-Sternberg (HRS) cells and in the various non-malignant cells present in HD biopsies, a relationship between expression of IL-6 by the tumour and outcome measures has not been established. The study group comprised of 97 patients with advanced HD who were recruited to two related clinical trials. IL-6 expression was determined on paraffin-wax sections of biopsy material by means of an immunohistochemical assay. Of the 97 patients, 27 (28%) showed staining for IL-6 in HRS cells. IL-6 expression by HRS cells was significantly correlated with a decreased likelihood of achieving a complete response to chemotherapy (P = 0.02) and with an increased prevalence of 'B' symptoms (P = 0.04). IL-6 expression by HRS cells was not associated with Epstein-Barr virus status (P = 0.57). In summary, the results suggest that IL-6 expression by HRS cells may contribute to the presence of 'B' symptoms and to a decreased likelihood to achieve a complete remission in HD patients.
Type: Article
Language: en
Keywords: Hodgkin's Disease
Interleukin 6
Immunohistochemistry
B symptoms
Remission
MeSH: Adult
Antineoplastic Combined Chemotherapy Protocols
Biological Markers
Disease-Free Survival
Epstein-Barr Virus Infections
Female
Humans
Immunohistochemistry
Interleukin-6
Male
Middle Aged
Prognosis
Reed-Sternberg Cells
Regression Analysis
Remission Induction
ISSN: 0007-1048
Appears in Collections: Molecular Immunology Research Group

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