Wolverhampton Intellectual Repository and E-Theses >
Research Institutes >
Research Institute in Healthcare Science >
Molecular Immunology Research Group >
Interleukin 6 expression by Hodgkin/Reed-Sternberg cells is associated with the presence of 'B' symptoms and failure to achieve complete remission in patients with advanced Hodgkin's disease.
this identifier to cite or link
to this item:
|Title: ||Interleukin 6 expression by Hodgkin/Reed-Sternberg cells is associated with the presence of 'B' symptoms and failure to achieve complete remission in patients with advanced Hodgkin's disease.|
|Citation: ||British Journal of Haematology, 118 (1): 195-201|
|Publisher: ||Blackwell Synergy|
|Journal: ||British Journal of Haematology|
|Issue Date: ||2002 |
|PubMed ID: ||12100148|
|Additional Links: ||http://www.ingentaconnect.com/content/bsc/bjh/2002/00000118/00000001/art00027?token=0051107f39412f415d487725737b742b2f423f5142253048296a7c2849266d656cc66329cb2bf6951|
|Abstract: ||Interleukin 6 (IL-6) is a potent immunomodulatory cytokine that has pathogenic and prognostic significance in a number of disorders. Previous studies in Hodgkin's disease (HD) have demonstrated the association between elevated serum levels of IL-6 and unfavourable prognosis, including advanced stage and the presence of 'B' symptoms and with reduced survival. Although IL-6 expression has been demonstrated in both the malignant Hodgkin/Reed-Sternberg (HRS) cells and in the various non-malignant cells present in HD biopsies, a relationship between expression of IL-6 by the tumour and outcome measures has not been established. The study group comprised of 97 patients with advanced HD who were recruited to two related clinical trials. IL-6 expression was determined on paraffin-wax sections of biopsy material by means of an immunohistochemical assay. Of the 97 patients, 27 (28%) showed staining for IL-6 in HRS cells. IL-6 expression by HRS cells was significantly correlated with a decreased likelihood of achieving a complete response to chemotherapy (P = 0.02) and with an increased prevalence of 'B' symptoms (P = 0.04). IL-6 expression by HRS cells was not associated with Epstein-Barr virus status (P = 0.57). In summary, the results suggest that IL-6 expression by HRS cells may contribute to the presence of 'B' symptoms and to a decreased likelihood to achieve a complete remission in HD patients.|
|Keywords: ||Hodgkin's Disease|
Antineoplastic Combined Chemotherapy Protocols
Epstein-Barr Virus Infections
|Appears in Collections: ||Molecular Immunology Research Group |
|Files in This Item:|
There are no files associated with this item.
|Related articles on PubMed|
Interleukin-10 levels are often elevated in serum of adults with Hodgkin's disease and are associated with inferior failure-free survival.
Sarris AH, Kliche KO, Pethambaram P, Preti A, Tucker S, Jackow C, Messina O, Pugh W, Hagemeister FB, McLaughlin P, Rodriguez MA, Romaguera J, Fritsche H, Witzig T, Duvic M, Andreeff M, Cabanillas F
|See all 179 articles|
All Items in WIRE are protected by copyright, with all rights reserved, unless otherwise indicated.