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Interleukin 6 expression by Hodgkin/Reed-Sternberg cells is associated with the presence of 'B' symptoms and failure to achieve complete remission in patients with advanced Hodgkin's disease.
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|Title: ||Interleukin 6 expression by Hodgkin/Reed-Sternberg cells is associated with the presence of 'B' symptoms and failure to achieve complete remission in patients with advanced Hodgkin's disease.|
|Citation: ||British Journal of Haematology, 118 (1): 195-201|
|Publisher: ||Blackwell Synergy|
|Journal: ||British Journal of Haematology|
|Issue Date: ||2002 |
|PubMed ID: ||12100148|
|Additional Links: ||http://www.ingentaconnect.com/content/bsc/bjh/2002/00000118/00000001/art00027?token=0051107f39412f415d487725737b742b2f423f5142253048296a7c2849266d656cc66329cb2bf6951|
|Abstract: ||Interleukin 6 (IL-6) is a potent immunomodulatory cytokine that has pathogenic and prognostic significance in a number of disorders. Previous studies in Hodgkin's disease (HD) have demonstrated the association between elevated serum levels of IL-6 and unfavourable prognosis, including advanced stage and the presence of 'B' symptoms and with reduced survival. Although IL-6 expression has been demonstrated in both the malignant Hodgkin/Reed-Sternberg (HRS) cells and in the various non-malignant cells present in HD biopsies, a relationship between expression of IL-6 by the tumour and outcome measures has not been established. The study group comprised of 97 patients with advanced HD who were recruited to two related clinical trials. IL-6 expression was determined on paraffin-wax sections of biopsy material by means of an immunohistochemical assay. Of the 97 patients, 27 (28%) showed staining for IL-6 in HRS cells. IL-6 expression by HRS cells was significantly correlated with a decreased likelihood of achieving a complete response to chemotherapy (P = 0.02) and with an increased prevalence of 'B' symptoms (P = 0.04). IL-6 expression by HRS cells was not associated with Epstein-Barr virus status (P = 0.57). In summary, the results suggest that IL-6 expression by HRS cells may contribute to the presence of 'B' symptoms and to a decreased likelihood to achieve a complete remission in HD patients.|
|Keywords: ||Hodgkin's Disease|
Antineoplastic Combined Chemotherapy Protocols
Epstein-Barr Virus Infections
|Appears in Collections: ||Molecular Immunology Research Group |
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