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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Pharmacy and Natural Products Research Group > Cholesterol-bile salt vesicles as potential delivery vehicles for drug and vaccine delivery.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/29444
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Title: Cholesterol-bile salt vesicles as potential delivery vehicles for drug and vaccine delivery.
Authors: Martin, C.
Thongborisute, J.
Takeuchi, H.
Yamamoto, H.
Kawashima, Y.
Alpar, H.O.
Citation: International Journal of Pharmaceutics, 298(2): 339-343
Publisher: Elsevier Science Direct
Journal: International Journal of Pharmaceutics
Issue Date: 2005
URI: http://hdl.handle.net/2436/29444
DOI: 10.1016/j.ijpharm.2005.03.038
PubMed ID: 15967607
Additional Links: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T7W-4GFCPVT-1&_user=1644469&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000054077&_version=1&_urlVersion=0&_userid=1644469&md5=af750868585f0a5f9ff74c005d4e33a7
Abstract: The aim of this study was to further investigate the interactions between cholesterol (CH) and mixed bile salts (BS) (sodium cholate and sodium deoxycholate) and their suitability for drug and vaccine delivery. Insulin was used as a model protein to assess the ability of CH:BS vesicles to entrap a therapeutically relevant macromolecule. The association of protein (FITC-insulin) with the CH:BS structure was confirmed with fluorescence microscopy, and the overall morphology of the vesicles was examined with atomic force microscopy (AFM). Results demonstrate that the nature of the vesicles formed between CH and BS is dependent not only on the concentration of BS but also on the increasing CH concentration leading to CH crystal formation.
Type: Article
Language: en
Keywords: Cholesterol
Vaccine delivery
MeSH: Bile Acids and Salts
Cholesterol
Drug Delivery Systems
Electrochemistry
Fluorescein-5-isothiocyanate
Insulin
Micelles
Microscopy, Atomic Force
Microscopy, Fluorescence
Vaccines
Vehicles
ISSN: 0378-5173
Appears in Collections: Pharmacy and Natural Products Research Group

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