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Wolverhampton Intellectual Repository and E-Theses > School of Health & Wellbeing > Centre for Health and Social Care Improvement > High diversity of non-human leukocyte antigens in transplant-associated coronary artery disease.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/29437
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Title: High diversity of non-human leukocyte antigens in transplant-associated coronary artery disease.
Authors: Bates, Ruth L.
Frampton, Geoffrey
Rose, Marlene L.
Murphy, John J.
Citation: Transplantation, 75(8): 1347-1350
Publisher: Lippincott Williams & Wilkins
Journal: Transplantation
Issue Date: 2003
URI: http://hdl.handle.net/2436/29437
DOI: 10.1097/01.TP.0000061790.08550.EC
PubMed ID: 12717228
Additional Links: http://www.transplantjournal.com/pt/re/transplantation/abstract.00007890-200304270-00057.htm
Abstract: BACKGROUND: Antibodies to endothelial derived non-human leukocyte antigens (HLA) have been associated with transplant (Tx)-associated coronary artery disease (CAD) after cardiac transplantation; however, few have been identified. The aim of this study was to screen a human coronary artery endothelial cell cDNA library with patient sera to establish the diversity and nature of the target antigens. METHODS: A human coronary artery endothelial cell cDNA library was screened with sera from seven long-term cardiac transplant patients with angiographically diagnosed TxCAD and sera from five healthy volunteers. RESULTS: Of the seven patients' sera, five showed reactivity, as did sera from two of the five normal subjects. Eighteen positive cDNA clones were isolated by TxCAD sera; DNA sequence analysis and DNA database searching identified all but one clone; 16 were nuclear or cytoplasmic proteins and 1 of them was the cell surface protein neuropilin 2. Five clones were targeted by normal sera. A different spectrum of reactive clones was identified by the sera of each patient where reactive clones were evident. CONCLUSIONS: A high diversity of non-HLA antigens, probably autoantigens, are involved in the pathogenesis of TxCAD.
Type: Article
Language: en
MeSH: Adult
Antigens
Coronary Disease
Cytoplasm
Gene Library
Heart Transplantation
Humans
Middle Aged
Neuropilin-2
Nuclear Proteins
Proteins
Reference Values
ISSN: 0041-1337
Appears in Collections: Centre for Health and Social Care Improvement

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