Acute rise of circulating vascular endothelial growth factor-A in patients with coronary artery disease following cardiothoracic surgery.

2.50
Hdl Handle:
http://hdl.handle.net/2436/29434
Title:
Acute rise of circulating vascular endothelial growth factor-A in patients with coronary artery disease following cardiothoracic surgery.
Authors:
Cotton, James M.; Mathur, A.; Hong, Ying; Brown, Angie S.; Martin, John F.; Erusalimsky, Jorge D.
Abstract:
AIMS: Vascular endothelial growth factor-A (VEGF-A) is an angiogenic and vasoprotective molecule whose expression is modulated by hypoxia and inflammatory mediators. Here we have tested the hypothesis that plasma levels of VEGF-A are influenced by pre-existing coronary artery disease and by changes in circulating interleukin-6 (IL-6). METHODS AND RESULTS: Plasma VEGF-A and IL-6 were measured prior to and at various time intervals following surgery in individuals with angiographically normal coronary arteries requiring cardiac valve replacement (N group) and in patients with coronary artery disease and stable angina undergoing coronary artery bypass grafting (CAD group). Baseline VEGF-A levels were not significantly different in CAD (22.3+/-2.6 pg x ml(-1)) compared to the N group (14.9+/-2.9 pg x ml(-1)). Following cardiac surgery there was a significant rise of VEGF-A in CAD (P<0.0005 vs baseline), but not in the N group, reaching a maximum (approximately 2 fold increase) after 24 h. Surgery caused a rapid increase of plasma IL-6 in both groups, but the rise was significantly larger in CAD patients (P<0.0005 vs N) where it preceded the increase in VEGF-A. Furthermore, in patients with CAD there was a significant correlation between the change in VEGF-A and the change in IL-6 (P<0.04). CONCLUSION: These findings demonstrate that in patients with coronary artery disease cardiothoracic surgery leads to an acute rise in VEGF-A. We suggest that this rise may result from an interaction between the pre-existing atheromatous process and a systemic increase of inflammatory mediators.
Citation:
European Heart Journal, 23(12): 953-959
Publisher:
Oxford Journals
Journal:
European Heart Journal
URI:
http://hdl.handle.net/2436/29434
DOI:
10.1053/euhj.2001.3034
PubMed ID:
12069450
Additional Links:
http://eurheartj.oxfordjournals.org/cgi/reprint/23/12/953
Type:
Article
Language:
en
ISSN:
0195-668X
Appears in Collections:
Centre for Health and Social Care Improvement

Full metadata record

DC FieldValue Language
dc.contributor.authorCotton, James M.-
dc.contributor.authorMathur, A.-
dc.contributor.authorHong, Ying-
dc.contributor.authorBrown, Angie S.-
dc.contributor.authorMartin, John F.-
dc.contributor.authorErusalimsky, Jorge D.-
dc.date.accessioned2008-06-04T08:57:31Z-
dc.date.available2008-06-04T08:57:31Z-
dc.identifier.citationEuropean Heart Journal, 23(12): 953-959en
dc.identifier.issn0195-668X-
dc.identifier.pmid12069450-
dc.identifier.doi10.1053/euhj.2001.3034-
dc.identifier.urihttp://hdl.handle.net/2436/29434-
dc.description.abstractAIMS: Vascular endothelial growth factor-A (VEGF-A) is an angiogenic and vasoprotective molecule whose expression is modulated by hypoxia and inflammatory mediators. Here we have tested the hypothesis that plasma levels of VEGF-A are influenced by pre-existing coronary artery disease and by changes in circulating interleukin-6 (IL-6). METHODS AND RESULTS: Plasma VEGF-A and IL-6 were measured prior to and at various time intervals following surgery in individuals with angiographically normal coronary arteries requiring cardiac valve replacement (N group) and in patients with coronary artery disease and stable angina undergoing coronary artery bypass grafting (CAD group). Baseline VEGF-A levels were not significantly different in CAD (22.3+/-2.6 pg x ml(-1)) compared to the N group (14.9+/-2.9 pg x ml(-1)). Following cardiac surgery there was a significant rise of VEGF-A in CAD (P<0.0005 vs baseline), but not in the N group, reaching a maximum (approximately 2 fold increase) after 24 h. Surgery caused a rapid increase of plasma IL-6 in both groups, but the rise was significantly larger in CAD patients (P<0.0005 vs N) where it preceded the increase in VEGF-A. Furthermore, in patients with CAD there was a significant correlation between the change in VEGF-A and the change in IL-6 (P<0.04). CONCLUSION: These findings demonstrate that in patients with coronary artery disease cardiothoracic surgery leads to an acute rise in VEGF-A. We suggest that this rise may result from an interaction between the pre-existing atheromatous process and a systemic increase of inflammatory mediators.en
dc.language.isoenen
dc.publisherOxford Journalsen
dc.relation.urlhttp://eurheartj.oxfordjournals.org/cgi/reprint/23/12/953en
dc.subject.meshAgeden
dc.subject.meshBiological Markersen
dc.subject.meshCardiac Surgical Proceduresen
dc.subject.meshCoronary Artery Diseaseen
dc.subject.meshEndothelial Growth Factorsen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshInterleukin-6en
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshP-Selectinen
dc.subject.meshPostoperative Perioden
dc.subject.meshVascular Endothelial Growth Factor Aen
dc.titleAcute rise of circulating vascular endothelial growth factor-A in patients with coronary artery disease following cardiothoracic surgery.en
dc.typeArticleen
dc.identifier.journalEuropean Heart Journalen

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