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Wolverhampton Intellectual Repository and E-Theses > School of Health & Wellbeing > Centre for Health and Social Care Improvement > Acute rise of circulating vascular endothelial growth factor-A in patients with coronary artery disease following cardiothoracic surgery.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/29434
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Title: Acute rise of circulating vascular endothelial growth factor-A in patients with coronary artery disease following cardiothoracic surgery.
Authors: Cotton, James M.
Mathur, A.
Hong, Ying
Brown, Angie S.
Martin, John F.
Erusalimsky, Jorge D.
Citation: European Heart Journal, 23(12): 953-959
Publisher: Oxford Journals
Journal: European Heart Journal
URI: http://hdl.handle.net/2436/29434
DOI: 10.1053/euhj.2001.3034
PubMed ID: 12069450
Additional Links: http://eurheartj.oxfordjournals.org/cgi/reprint/23/12/953
Abstract: AIMS: Vascular endothelial growth factor-A (VEGF-A) is an angiogenic and vasoprotective molecule whose expression is modulated by hypoxia and inflammatory mediators. Here we have tested the hypothesis that plasma levels of VEGF-A are influenced by pre-existing coronary artery disease and by changes in circulating interleukin-6 (IL-6). METHODS AND RESULTS: Plasma VEGF-A and IL-6 were measured prior to and at various time intervals following surgery in individuals with angiographically normal coronary arteries requiring cardiac valve replacement (N group) and in patients with coronary artery disease and stable angina undergoing coronary artery bypass grafting (CAD group). Baseline VEGF-A levels were not significantly different in CAD (22.3+/-2.6 pg x ml(-1)) compared to the N group (14.9+/-2.9 pg x ml(-1)). Following cardiac surgery there was a significant rise of VEGF-A in CAD (P<0.0005 vs baseline), but not in the N group, reaching a maximum (approximately 2 fold increase) after 24 h. Surgery caused a rapid increase of plasma IL-6 in both groups, but the rise was significantly larger in CAD patients (P<0.0005 vs N) where it preceded the increase in VEGF-A. Furthermore, in patients with CAD there was a significant correlation between the change in VEGF-A and the change in IL-6 (P<0.04). CONCLUSION: These findings demonstrate that in patients with coronary artery disease cardiothoracic surgery leads to an acute rise in VEGF-A. We suggest that this rise may result from an interaction between the pre-existing atheromatous process and a systemic increase of inflammatory mediators.
Type: Article
Language: en
MeSH: Aged
Biological Markers
Cardiac Surgical Procedures
Coronary Artery Disease
Endothelial Growth Factors
Female
Humans
Interleukin-6
Male
Middle Aged
P-Selectin
Postoperative Period
Vascular Endothelial Growth Factor A
ISSN: 0195-668X
Appears in Collections: Centre for Health and Social Care Improvement

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