No correlation between circulating ACE activity and VO2max or mechanical efficiency in women.

2.50
Hdl Handle:
http://hdl.handle.net/2436/22861
Title:
No correlation between circulating ACE activity and VO2max or mechanical efficiency in women.
Authors:
Day, Stephen H.; Gohlke, Peter; Dhamrait, Sukhbir S.; Williams, Alun G.
Abstract:
The insertion (I) variant of the angiotensin-1 converting enzyme (ACE) I/D genetic polymorphism is associated with lower circulating and tissue ACE activity. Some studies have also suggested associations of ACE I/D genotype with endurance phenotypes. This study assessed the relationships between circulating ACE activity, ACE I/D genotype, mechanical efficiency and the maximal rate of oxygen uptake in sedentary individuals. Sixty-two untrained women were tested for mechanical efficiency during submaximal cycle ergometry (delta and gross efficiencies during exercise between 40 and 80 W) and the maximal rate of oxygen uptake during incremental treadmill running. Respiratory variables were measured using indirect calorimetry. Venous blood was obtained for direct assay of circulating ACE activity, allowing for the assessment of correlations between two continuous variables, rather than a categorical analysis of endurance phenotype by genotype alone. ACE I/D genotype was also determined, and was strongly associated with circulating ACE activity (P < 0.0005). Neither circulating ACE activity (27.4 +/- 8.4 nM His-Leu-ml(-1)) nor ACE genotype showed a statistically significant association with any of the endurance phenotypes measured. The weak correlations observed included r = -0.122 (P = 0.229) for the relationship between delta efficiency (23.9 +/- 2.5%) and circulating ACE activity and r = 0.134 (P > 0.6) for the relationship between maximal aerobic power (149.1 +/- 22.9 ml kg(-2/3) min(-1)) and circulating ACE activity. The data do not support a role for systemic ACE activity in the regulation of endurance performance in sedentary individuals, extending this observation to a large female cohort.
Citation:
European Journal of Applied Physiology, 99 (1): 11-18
Publisher:
Springer
Journal:
European Journal of Applied Physiology
Issue Date:
2007
URI:
http://hdl.handle.net/2436/22861
DOI:
10.1007/s00421-006-0309-3
PubMed ID:
17006710
Additional Links:
http://www.springerlink.com/content/fn831636n85684l5/
Type:
Article
Language:
en
ISSN:
1439-6319
Appears in Collections:
Exercise and Health

Full metadata record

DC FieldValue Language
dc.contributor.authorDay, Stephen H.-
dc.contributor.authorGohlke, Peter-
dc.contributor.authorDhamrait, Sukhbir S.-
dc.contributor.authorWilliams, Alun G.-
dc.date.accessioned2008-04-10T10:45:49Z-
dc.date.available2008-04-10T10:45:49Z-
dc.date.issued2007-
dc.identifier.citationEuropean Journal of Applied Physiology, 99 (1): 11-18en
dc.identifier.issn1439-6319-
dc.identifier.pmid17006710-
dc.identifier.doi10.1007/s00421-006-0309-3-
dc.identifier.urihttp://hdl.handle.net/2436/22861-
dc.description.abstractThe insertion (I) variant of the angiotensin-1 converting enzyme (ACE) I/D genetic polymorphism is associated with lower circulating and tissue ACE activity. Some studies have also suggested associations of ACE I/D genotype with endurance phenotypes. This study assessed the relationships between circulating ACE activity, ACE I/D genotype, mechanical efficiency and the maximal rate of oxygen uptake in sedentary individuals. Sixty-two untrained women were tested for mechanical efficiency during submaximal cycle ergometry (delta and gross efficiencies during exercise between 40 and 80 W) and the maximal rate of oxygen uptake during incremental treadmill running. Respiratory variables were measured using indirect calorimetry. Venous blood was obtained for direct assay of circulating ACE activity, allowing for the assessment of correlations between two continuous variables, rather than a categorical analysis of endurance phenotype by genotype alone. ACE I/D genotype was also determined, and was strongly associated with circulating ACE activity (P < 0.0005). Neither circulating ACE activity (27.4 +/- 8.4 nM His-Leu-ml(-1)) nor ACE genotype showed a statistically significant association with any of the endurance phenotypes measured. The weak correlations observed included r = -0.122 (P = 0.229) for the relationship between delta efficiency (23.9 +/- 2.5%) and circulating ACE activity and r = 0.134 (P > 0.6) for the relationship between maximal aerobic power (149.1 +/- 22.9 ml kg(-2/3) min(-1)) and circulating ACE activity. The data do not support a role for systemic ACE activity in the regulation of endurance performance in sedentary individuals, extending this observation to a large female cohort.en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urlhttp://www.springerlink.com/content/fn831636n85684l5/en
dc.subjectAngiotensin-1 converting enzymeen
dc.subjectAerobic capacityen
dc.subjectEnduranceen
dc.subjectGeneticsen
dc.subject.meshAdulten
dc.subject.meshCohort Studiesen
dc.subject.meshExerciseen
dc.subject.meshExercise Testen
dc.subject.meshFemaleen
dc.subject.meshGenotypeen
dc.subject.meshHumansen
dc.subject.meshMuscle, Skeletalen
dc.subject.meshOxygen Consumptionen
dc.subject.meshPeptidyl-Dipeptidase Aen
dc.subject.meshPhenotypeen
dc.subject.meshPhysical Enduranceen
dc.subject.meshPhysical Fitnessen
dc.subject.meshPolymorphism, Geneticen
dc.titleNo correlation between circulating ACE activity and VO2max or mechanical efficiency in women.en
dc.typeArticleen
dc.identifier.journalEuropean Journal of Applied Physiologyen

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