2.50
Hdl Handle:
http://hdl.handle.net/2436/22860
Title:
Circulating angiotensin converting enzyme activity is correlated with muscle strength.
Authors:
Williams, Alun G.; Day, Stephen H.; Folland, Jonathan P.; Gohlke, Peter; Dhamrait, Sukhbir S.; Montgomery, Hugh E.
Abstract:
PURPOSE: The D-variant of the angiotensin-1 converting enzyme (ACE) gene is associated with higher circulating and tissue ACE activity. Some studies have suggested a similar association of genotype with muscle strength or the gain in strength in response to training. This study has assessed the relationship between circulating ACE activity, strength, and the response to training. METHODS: Eighty-one untrained men were tested for quadriceps muscle strength, and 44 of these performed an 8-wk program of dynamic strength training of the quadriceps muscle group. Venous blood was obtained for assessment of circulating ACE activity before and after the training program. ACE genotype was also determined. RESULTS: At baseline, circulating ACE activity was significantly correlated with isometric (r = 0.25-0.29, P < 0.02) and isokinetic (r = 0.38, P < 0.0005) quadriceps muscle strength. ACE genotype also seemed to be related to pretraining muscle strength. However, circulating ACE activity showed no significant association with the 9-14% mean increases of muscle strength in response to the training intervention. ACE genotype also showed no association with the training-induced change in muscle strength. Circulating ACE activity did not change significantly after the training program. CONCLUSIONS: The data support a role for ACE in the regulation of human skeletal muscle strength, but do not confirm a role in altering the response to short-term training.
Citation:
Medicine and Science in Sports and Exercise, 37(6): 944-948
Publisher:
Lippincott Williams & Wilkins
Journal:
Medicine and Science in Sports and Exercise
Issue Date:
2005
URI:
http://hdl.handle.net/2436/22860
PubMed ID:
15947718
Additional Links:
http://www.acsm-msse.org/pt/re/msse/abstract.00005768-200506000-00007.htm
Type:
Article
Language:
en
ISSN:
0195-9131
Appears in Collections:
Exercise and Health

Full metadata record

DC FieldValue Language
dc.contributor.authorWilliams, Alun G.-
dc.contributor.authorDay, Stephen H.-
dc.contributor.authorFolland, Jonathan P.-
dc.contributor.authorGohlke, Peter-
dc.contributor.authorDhamrait, Sukhbir S.-
dc.contributor.authorMontgomery, Hugh E.-
dc.date.accessioned2008-04-10T10:33:57Z-
dc.date.available2008-04-10T10:33:57Z-
dc.date.issued2005-
dc.identifier.citationMedicine and Science in Sports and Exercise, 37(6): 944-948en
dc.identifier.issn0195-9131-
dc.identifier.pmid15947718-
dc.identifier.urihttp://hdl.handle.net/2436/22860-
dc.description.abstractPURPOSE: The D-variant of the angiotensin-1 converting enzyme (ACE) gene is associated with higher circulating and tissue ACE activity. Some studies have suggested a similar association of genotype with muscle strength or the gain in strength in response to training. This study has assessed the relationship between circulating ACE activity, strength, and the response to training. METHODS: Eighty-one untrained men were tested for quadriceps muscle strength, and 44 of these performed an 8-wk program of dynamic strength training of the quadriceps muscle group. Venous blood was obtained for assessment of circulating ACE activity before and after the training program. ACE genotype was also determined. RESULTS: At baseline, circulating ACE activity was significantly correlated with isometric (r = 0.25-0.29, P < 0.02) and isokinetic (r = 0.38, P < 0.0005) quadriceps muscle strength. ACE genotype also seemed to be related to pretraining muscle strength. However, circulating ACE activity showed no significant association with the 9-14% mean increases of muscle strength in response to the training intervention. ACE genotype also showed no association with the training-induced change in muscle strength. Circulating ACE activity did not change significantly after the training program. CONCLUSIONS: The data support a role for ACE in the regulation of human skeletal muscle strength, but do not confirm a role in altering the response to short-term training.en
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen
dc.relation.urlhttp://www.acsm-msse.org/pt/re/msse/abstract.00005768-200506000-00007.htmen
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshExerciseen
dc.subject.meshHumansen
dc.subject.meshJapanen
dc.subject.meshMaleen
dc.subject.meshMuscle, Skeletalen
dc.subject.meshPeptidyl-Dipeptidase Aen
dc.titleCirculating angiotensin converting enzyme activity is correlated with muscle strength.en
dc.typeArticleen
dc.identifier.journalMedicine and Science in Sports and Exerciseen

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