2.50
Hdl Handle:
http://hdl.handle.net/2436/22858
Title:
Bradykinin receptor gene variant and human physical performance.
Authors:
Williams, Alun G.; Dhamrait, Sukhbir S.; Wootton, Peter T. E.; Day, Stephen H.; Hawe, Emma; Payne, John R.; Myerson, Saul G.; World, Michael; Budgett, Richard; Humphries, Steve E.; Montgomery, Hugh E.
Abstract:
Accumulating evidence suggests that athletic performance is strongly influenced by genetic variation. One such locus of influence is the gene for angiotensin-I converting enzyme (ACE), which exhibits a common variant [ACE insertion (I)/deletion (D)]. ACE can drive formation of vasoconstrictor ANG II but preferentially degrades vasodilator bradykinin. The ACE I allele is associated with higher kinin activity. A common gene variant in the kinin beta(2) receptor (B(2)R) exists: the -9 as opposed to +9 allele is associated with higher receptor mRNA expression. We tested whether this variant was associated with the efficiency of muscular contraction [delta efficiency (DE)] in 115 healthy men and women, or with running distance among 81 Olympic standard track athletes. We further sought evidence of biological interaction with ACE I/D genotype. DE was highly significantly associated with B(2)R genotype (23.84 +/- 2.41 vs. 24.25 +/- 2.81 vs. 26.05 +/- 2.26% for those of +9/+9 vs. +9/-9 vs. -9/-9 genotype; n = 25, 61, and 29, respectively; P = 0.0008 for ANOVA adjusted for sex). There was evidence for interaction with ACE I/D genotype, with individuals who were ACE II, with B(2)R -9/-9 having the highest DE at baseline. The ACE I/B(2)R -9 "high kinin receptor activity" haplotype was significantly associated with endurance (predominantly aerobic) event among elite athletes (P = 0.003). These data suggest that common genetic variation in the B(2)R is associated with efficiency of skeletal muscle contraction and with distance event of elite track athletes and that at least part of the associations of ACE and fitness phenotypes is through elevation of kinin activity.
Citation:
Journal of Applied Physiology, 96(3): 938-942
Publisher:
The American Physiological Society/HighWire Press
Journal:
Journal of Applied Physiology
Issue Date:
2004
URI:
http://hdl.handle.net/2436/22858
DOI:
10.1152/japplphysiol.00865.2003
PubMed ID:
14607851
Additional Links:
http://jap.physiology.org/; http://jap.physiology.org/cgi/content/full/96/3/938
Type:
Article
Language:
en
ISSN:
8750-7587
Appears in Collections:
Exercise and Health

Full metadata record

DC FieldValue Language
dc.contributor.authorWilliams, Alun G.-
dc.contributor.authorDhamrait, Sukhbir S.-
dc.contributor.authorWootton, Peter T. E.-
dc.contributor.authorDay, Stephen H.-
dc.contributor.authorHawe, Emma-
dc.contributor.authorPayne, John R.-
dc.contributor.authorMyerson, Saul G.-
dc.contributor.authorWorld, Michael-
dc.contributor.authorBudgett, Richard-
dc.contributor.authorHumphries, Steve E.-
dc.contributor.authorMontgomery, Hugh E.-
dc.date.accessioned2008-04-10T10:16:07Z-
dc.date.available2008-04-10T10:16:07Z-
dc.date.issued2004-
dc.identifier.citationJournal of Applied Physiology, 96(3): 938-942en
dc.identifier.issn8750-7587-
dc.identifier.pmid14607851-
dc.identifier.doi10.1152/japplphysiol.00865.2003-
dc.identifier.urihttp://hdl.handle.net/2436/22858-
dc.description.abstractAccumulating evidence suggests that athletic performance is strongly influenced by genetic variation. One such locus of influence is the gene for angiotensin-I converting enzyme (ACE), which exhibits a common variant [ACE insertion (I)/deletion (D)]. ACE can drive formation of vasoconstrictor ANG II but preferentially degrades vasodilator bradykinin. The ACE I allele is associated with higher kinin activity. A common gene variant in the kinin beta(2) receptor (B(2)R) exists: the -9 as opposed to +9 allele is associated with higher receptor mRNA expression. We tested whether this variant was associated with the efficiency of muscular contraction [delta efficiency (DE)] in 115 healthy men and women, or with running distance among 81 Olympic standard track athletes. We further sought evidence of biological interaction with ACE I/D genotype. DE was highly significantly associated with B(2)R genotype (23.84 +/- 2.41 vs. 24.25 +/- 2.81 vs. 26.05 +/- 2.26% for those of +9/+9 vs. +9/-9 vs. -9/-9 genotype; n = 25, 61, and 29, respectively; P = 0.0008 for ANOVA adjusted for sex). There was evidence for interaction with ACE I/D genotype, with individuals who were ACE II, with B(2)R -9/-9 having the highest DE at baseline. The ACE I/B(2)R -9 "high kinin receptor activity" haplotype was significantly associated with endurance (predominantly aerobic) event among elite athletes (P = 0.003). These data suggest that common genetic variation in the B(2)R is associated with efficiency of skeletal muscle contraction and with distance event of elite track athletes and that at least part of the associations of ACE and fitness phenotypes is through elevation of kinin activity.en
dc.language.isoenen
dc.publisherThe American Physiological Society/HighWire Pressen
dc.relation.urlhttp://jap.physiology.org/en
dc.relation.urlhttp://jap.physiology.org/cgi/content/full/96/3/938en
dc.subjectPolymorphismen
dc.subjectAngiotensin-converting enzymeen
dc.subjectSkeletal muscleen
dc.subjectElite athleteen
dc.subjectAthletes-
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAnalysis of Varianceen
dc.subject.meshChi-Square Distributionen
dc.subject.meshExercise Testen
dc.subject.meshFemaleen
dc.subject.meshGenotypeen
dc.subject.meshHaplotypesen
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshPeptidyl-Dipeptidase Aen
dc.subject.meshReceptors, Bradykininen
dc.subject.meshRunningen
dc.subject.meshSportsen
dc.subject.meshVariation (Genetics)en
dc.titleBradykinin receptor gene variant and human physical performance.en
dc.typeArticleen
dc.identifier.journalJournal of Applied Physiologyen

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