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Wolverhampton Intellectual Repository and E-Theses > School of Sport, Performing Arts and Leisure > Research Centre for Sport, Exercise and Performance > Exercise and Health > Bradykinin receptor gene variant and human physical performance.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/22858
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Title: Bradykinin receptor gene variant and human physical performance.
Authors: Williams, Alun G.
Dhamrait, Sukhbir S.
Wootton, Peter T. E.
Day, Stephen H.
Hawe, Emma
Payne, John R.
Myerson, Saul G.
World, Michael
Budgett, Richard
Humphries, Steve E.
Montgomery, Hugh E.
Citation: Journal of Applied Physiology, 96(3): 938-942
Publisher: The American Physiological Society/HighWire Press
Journal: Journal of Applied Physiology
Issue Date: 2004
URI: http://hdl.handle.net/2436/22858
DOI: 10.1152/japplphysiol.00865.2003
PubMed ID: 14607851
Additional Links: http://jap.physiology.org/
http://jap.physiology.org/cgi/content/full/96/3/938
Abstract: Accumulating evidence suggests that athletic performance is strongly influenced by genetic variation. One such locus of influence is the gene for angiotensin-I converting enzyme (ACE), which exhibits a common variant [ACE insertion (I)/deletion (D)]. ACE can drive formation of vasoconstrictor ANG II but preferentially degrades vasodilator bradykinin. The ACE I allele is associated with higher kinin activity. A common gene variant in the kinin beta(2) receptor (B(2)R) exists: the -9 as opposed to +9 allele is associated with higher receptor mRNA expression. We tested whether this variant was associated with the efficiency of muscular contraction [delta efficiency (DE)] in 115 healthy men and women, or with running distance among 81 Olympic standard track athletes. We further sought evidence of biological interaction with ACE I/D genotype. DE was highly significantly associated with B(2)R genotype (23.84 +/- 2.41 vs. 24.25 +/- 2.81 vs. 26.05 +/- 2.26% for those of +9/+9 vs. +9/-9 vs. -9/-9 genotype; n = 25, 61, and 29, respectively; P = 0.0008 for ANOVA adjusted for sex). There was evidence for interaction with ACE I/D genotype, with individuals who were ACE II, with B(2)R -9/-9 having the highest DE at baseline. The ACE I/B(2)R -9 "high kinin receptor activity" haplotype was significantly associated with endurance (predominantly aerobic) event among elite athletes (P = 0.003). These data suggest that common genetic variation in the B(2)R is associated with efficiency of skeletal muscle contraction and with distance event of elite track athletes and that at least part of the associations of ACE and fitness phenotypes is through elevation of kinin activity.
Type: Article
Language: en
Keywords: Polymorphism
Angiotensin-converting enzyme
Skeletal muscle
Elite athlete
Athletes
MeSH: Adolescent
Adult
Analysis of Variance
Chi-Square Distribution
Exercise Test
Female
Genotype
Haplotypes
Humans
Male
Peptidyl-Dipeptidase A
Receptors, Bradykinin
Running
Sports
Variation (Genetics)
ISSN: 8750-7587
Appears in Collections: Exercise and Health

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