2.50
Hdl Handle:
http://hdl.handle.net/2436/22857
Title:
Exercise-induced oxidative stress in G6PD-deficient individuals.
Authors:
Nikolaidis, Michalis G.; Jamurtas, Athanasios Z.; Paschalis, Vassilis; Kostaropoulos, Iason A.; Kladi-Skandali, Athina; Balamitsi, Vera; Koutedakis, Yiannis; Kouretas, Dimitris
Abstract:
PURPOSE: This study was designed to investigate whether individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency can exercise without greater perturbations in their redox status compared with non-G6PD-deficient individuals. METHODS: Nine males with established G6PD deficiency and nine males with normal G6PD activity performed two exhaustive treadmill exercise protocols of different duration (the shorter one lasting 12 min and the longer one 50 min). Several hematological parameters, reduced glutathione (GSH), oxidized glutathione (GSSG), thiobarbituric acid reactive substances (TBARS), protein carbonyls, catalase, and total antioxidant capacity (TAC) were measured in the blood before and after each exercise bout. RESULTS: Both GSH and GSSG were significantly higher in the control group compared with the G6PD-deficient group at baseline (0.404 +/- 0.101 vs 0.195 +/- 0.049 mmol.L(-1) for GSH and 0.047 +/- 0.012 vs 0.012 +/- 0.006 mmol.L(-1) for GSSG; P < 0.05); as a result, their ratio was not significantly different between the two groups (P > 0.05). All other oxidative stress indices were not different between groups at rest (P > 0.05). Exercise of both durations affected significantly (P < 0.05) and similarly the levels of all oxidative stress indices either in the G6PD-deficient group or in the control group. Only the long exercise affected GSH status significantly (P < 0.05), whereas both short and long exercise increased the levels of TBARS, protein carbonyls, catalase activity, and TAC to a similar extent (P < 0.05). CONCLUSION: G6PD-deficient individuals are able to exercise until exhaustion without higher oxidative stress compared with non-G6PD-deficient individuals. Exercise duration is an important determinant of the magnitude of exercise-induced changes for GSH, GSSG, and GSH/GSSG, but not for TBARS, protein carbonyls, catalase activity, or TAC.
Citation:
Medicine & Science in Sports & Exercise, 38(8): 1443-1450
Publisher:
Lippincott Williams & Wilkins
Journal:
Medicine & Science in Sports & Exercise
Issue Date:
2006
URI:
http://hdl.handle.net/2436/22857
DOI:
10.1249/01.mss.0000228938.24658.5f
PubMed ID:
16888458
Additional Links:
http://www.acsm-msse.org/pt/re/msse/abstract.00005768-200608000-00012.htm
Type:
Article
Language:
en
ISSN:
0195-9131
Appears in Collections:
Exercise and Health

Full metadata record

DC FieldValue Language
dc.contributor.authorNikolaidis, Michalis G.-
dc.contributor.authorJamurtas, Athanasios Z.-
dc.contributor.authorPaschalis, Vassilis-
dc.contributor.authorKostaropoulos, Iason A.-
dc.contributor.authorKladi-Skandali, Athina-
dc.contributor.authorBalamitsi, Vera-
dc.contributor.authorKoutedakis, Yiannis-
dc.contributor.authorKouretas, Dimitris-
dc.date.accessioned2008-04-10T09:22:48Z-
dc.date.available2008-04-10T09:22:48Z-
dc.date.issued2006-
dc.identifier.citationMedicine & Science in Sports & Exercise, 38(8): 1443-1450en
dc.identifier.issn0195-9131-
dc.identifier.pmid16888458-
dc.identifier.doi10.1249/01.mss.0000228938.24658.5f-
dc.identifier.urihttp://hdl.handle.net/2436/22857-
dc.description.abstractPURPOSE: This study was designed to investigate whether individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency can exercise without greater perturbations in their redox status compared with non-G6PD-deficient individuals. METHODS: Nine males with established G6PD deficiency and nine males with normal G6PD activity performed two exhaustive treadmill exercise protocols of different duration (the shorter one lasting 12 min and the longer one 50 min). Several hematological parameters, reduced glutathione (GSH), oxidized glutathione (GSSG), thiobarbituric acid reactive substances (TBARS), protein carbonyls, catalase, and total antioxidant capacity (TAC) were measured in the blood before and after each exercise bout. RESULTS: Both GSH and GSSG were significantly higher in the control group compared with the G6PD-deficient group at baseline (0.404 +/- 0.101 vs 0.195 +/- 0.049 mmol.L(-1) for GSH and 0.047 +/- 0.012 vs 0.012 +/- 0.006 mmol.L(-1) for GSSG; P < 0.05); as a result, their ratio was not significantly different between the two groups (P > 0.05). All other oxidative stress indices were not different between groups at rest (P > 0.05). Exercise of both durations affected significantly (P < 0.05) and similarly the levels of all oxidative stress indices either in the G6PD-deficient group or in the control group. Only the long exercise affected GSH status significantly (P < 0.05), whereas both short and long exercise increased the levels of TBARS, protein carbonyls, catalase activity, and TAC to a similar extent (P < 0.05). CONCLUSION: G6PD-deficient individuals are able to exercise until exhaustion without higher oxidative stress compared with non-G6PD-deficient individuals. Exercise duration is an important determinant of the magnitude of exercise-induced changes for GSH, GSSG, and GSH/GSSG, but not for TBARS, protein carbonyls, catalase activity, or TAC.en
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen
dc.relation.urlhttp://www.acsm-msse.org/pt/re/msse/abstract.00005768-200608000-00012.htmen
dc.subject.meshAnalysis of Varianceen
dc.subject.meshAntioxidantsen
dc.subject.meshCatalaseen
dc.subject.meshExerciseen
dc.subject.meshExercise Testen
dc.subject.meshGlucosephosphate Dehydrogenase Deficiencyen
dc.subject.meshGlutathione Disulfideen
dc.subject.meshHumansen
dc.subject.meshLipid Peroxidationen
dc.subject.meshMaleen
dc.subject.meshOxidative Stressen
dc.subject.meshProtein Carbonylationen
dc.subject.meshStatistics, Nonparametricen
dc.subject.meshThiobarbituric Acid Reactive Substancesen
dc.titleExercise-induced oxidative stress in G6PD-deficient individuals.en
dc.typeArticleen
dc.identifier.journalMedicine & Science in Sports & Exerciseen

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