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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Sport, Exercise and Health Research Group > Redefining overweight and obesity in rheumatoid arthritis patients

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/22713
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Title: Redefining overweight and obesity in rheumatoid arthritis patients
Authors: Stavropoulos-Kalinoglou, Antonios
Metsios, Giorgos S.
Koutedakis, Yiannis
Nevill, Alan M.
Douglas, Karen M. J.
Jamurtas, Athanasios Z.
van Zanten, J.
Labib, M.
Kitas, George D.
Citation: Annals of the Rheumatic Diseases, 66 (10): 1316-21
Publisher: BMJ Publishing
Journal: Annals of the Rheumatic Diseases
Issue Date: 2007
URI: http://hdl.handle.net/2436/22713
DOI: 10.1136/ard.2006.060319
PubMed ID: 17289757
Additional Links: http://ard.bmj.com/cgi/content/full/66/10/1316
Abstract: OBJECTIVES: To assess whether body mass index (BMI) and body fat (BF) differ between rheumatoid arthritis (RA) patients, patients with non-inflammatory arthritis (osteoarthritis, OA) and healthy individuals, and whether disease specific measures of adiposity are required to accurately reflect BF in these groups. METHODS: 641 individuals were assessed for BMI (kg/m(2)) and BF (bioelectrical impedance). Of them, 299 (174 RA, 43 OA and 82 healthy controls (HC)) formed the observation group and 342 (all RA) the validation group. RA disease characteristics were collected. RESULTS: ANOVA revealed significant differences between disease groups for BMI (p<0.05) and BF (p<0.001). ANCOVA showed that age accounted for the differences in BMI (F(1,294) = 5.10, p<0.05); age (F(1,293) = 22.43, p<0.001), sex (F(1,293) = 380.90, p<0.001) and disease (F(2, 293) = 18.7, p<0.001) accounted for the differences in BF. For a given BF, patients with RA exhibited BMI levels reduced by 1.83 kg/m(2) (p<0.001) compared to HC; there were no significant differences between OA and HC. A predictive model for BF was developed (R(2) = 0.769, p<0.001) and validated using limits of agreement Analysis against measured BF in the validation group (95%LIM(AG) = 6.17; CV = 8.94). CONCLUSIONS: In individuals with RA, BMI cut-off points should be reduced by 2 kg/m(2) (that is, to 23 kg/m(2) for overweight and 28 kg/m(2) for obesity). The equation developed can be used to accurately predict BF from BMI in RA patients. These findings may be important in the context of the cardiovascular comorbidity of RA.
Type: Article
Language: en
MeSH: Adipose Tissue
Age Factors
Arthritis, Rheumatoid
Body Mass Index
Female
Humans
Male
Middle Aged
Obesity
Osteoarthritis
Overweight
Predictive Value of Tests
Sex Factors
ISSN: 0003-4967
Appears in Collections: Sport, Exercise and Health Research Group
Exercise and Health
Learning and Teaching in Sport, Exercise and Performance

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