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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Cancer Research Group > Cloning of a novel gene encoding a C2H2 zinc finger protein that alleviates sensitivity to abiotic stresses in Aspergillus nidulans

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/22192
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Title: Cloning of a novel gene encoding a C2H2 zinc finger protein that alleviates sensitivity to abiotic stresses in Aspergillus nidulans
Authors: O'Neil, John D.
Bugno, Marcin
Stanley, Michele S.
Barham-Morris, Julia B.
Woodcock, Nicola A.
Clement, Darren J.
Clipson, Nicholas J. W.
Whitehead, Michael P.
Fincham, Daron A.
Hooley, Paul
Citation: Mycological Research, 106(4): 491-498
Publisher: Elsevier Science Direct
Journal: Mycological Research
Issue Date: 2002
URI: http://hdl.handle.net/2436/22192
DOI: 10.1017/S0953756202005701
Additional Links: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7XMR-4RR97B2-J&_user=1644469&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000054077&_version=1&_urlVersion=0&_userid=1644469&md5=af34e34456d8e3a7f9b82176773566fd
Abstract: We report the cloning and sequencing of a DNA fragment encoding a putative C2H2 zinc finger protein from Aspergillus nidulans. The gene was isolated by complementation cloning of a salt sensitive phenotype of the A. nidulans sltAl mutant. A 3.8 kb Pst I fragment that restored wild type salt tolerance contained one large open reading frame of 2202 bp. The predicted protein (StzA) from this reading frame comprises 698 amino acids and has three Zinc fingers along with a putative transcriptional activation domain rich in acidic amino acids. The corresponding sequence from a sltAl mutant contains a premature STOP codon resulting in loss of the putative transcriptional activator in the C-terminal region. The Zinc fingers show conserved motifs with a number of transcription factors including CreA from A. nidulans and the human Wilm's tumour susceptibility protein WT-1.
Type: Article
Language: en
Keywords: C2H2
Zinc fingers
Aspergillus nidulans
Proteins
Amino Acids
Abiotic stress
ISSN: 09537562
14698102
Appears in Collections: Cancer Research Group

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