2.50
Hdl Handle:
http://hdl.handle.net/2436/20395
Title:
B-type natriuretic peptide in reversible myocardial ischaemia.
Authors:
Chatha, K.; Alsoud, M.; Griffiths, M.J.; Elfatih, A.; Abozguia, K.; Horton, R.C.; Dunmore, Simon J.; Gama, R.
Abstract:
BACKGROUND: Coronary heart disease is associated with increased B-type natriuretic peptides (BNPs), and, although controversial, may cause exaggerated exercise-induced BNP secretion. We investigated BNP in relation to reversible myocardial ischaemia. Materials and methods: Serum N-terminal proBNP (NT-proBNP) was measured before and after an exercise electrocardiogram test (ETT) in 14 patients with and 45 patients without exercise-induced myocardial ischaemia. Statistical analysis was carried out on logarithmically transformed data. Results, however, are pre-transformed data. RESULTS: NT-proBNP increased with exercise both in ETT-positive patients (mean (SD) 71.4 (41.2) v 76.8 (44.0) ng/l; p<0.001) and ETT-negative patients (54.0 (61.2) v 60.1 (69.0) ng/l; p<0.001). Pre-exercise and post-exercise NT-proBNP were higher (p<0.05) in ETT-positive than in ETT-negative patients. Incremental NT-proBNP was similar in ETT-positive (4.7 (4.2) ng/l) and ETT-negative (6.2 (8.6) ng/l) patients. CONCLUSION: Serum NT-proBNP concentrations are higher in patients with exercise-induced myocardial ischaemia than in those without. Exercise-induced electrocardiographic myocardial ischaemia, however, is not associated with exaggerated BNP secretion.
Citation:
Journal of Clinical Pathology, 59(11): 1216-1217
Publisher:
BMJ Publishing
Issue Date:
2006
URI:
http://hdl.handle.net/2436/20395
DOI:
10.1136/jcp.2005.034702
PubMed ID:
17071810
Additional Links:
http://jcp.bmj.com/cgi/content/full/59/11/1216
Type:
Article
Language:
en
ISSN:
0021-9746
Appears in Collections:
Diabetes, Physiology and Molecular Medicine Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorChatha, K.-
dc.contributor.authorAlsoud, M.-
dc.contributor.authorGriffiths, M.J.-
dc.contributor.authorElfatih, A.-
dc.contributor.authorAbozguia, K.-
dc.contributor.authorHorton, R.C.-
dc.contributor.authorDunmore, Simon J.-
dc.contributor.authorGama, R.-
dc.date.accessioned2008-03-12T10:31:06Z-
dc.date.available2008-03-12T10:31:06Z-
dc.date.issued2006-
dc.identifier.citationJournal of Clinical Pathology, 59(11): 1216-1217en
dc.identifier.issn0021-9746-
dc.identifier.pmid17071810-
dc.identifier.doi10.1136/jcp.2005.034702-
dc.identifier.urihttp://hdl.handle.net/2436/20395-
dc.description.abstractBACKGROUND: Coronary heart disease is associated with increased B-type natriuretic peptides (BNPs), and, although controversial, may cause exaggerated exercise-induced BNP secretion. We investigated BNP in relation to reversible myocardial ischaemia. Materials and methods: Serum N-terminal proBNP (NT-proBNP) was measured before and after an exercise electrocardiogram test (ETT) in 14 patients with and 45 patients without exercise-induced myocardial ischaemia. Statistical analysis was carried out on logarithmically transformed data. Results, however, are pre-transformed data. RESULTS: NT-proBNP increased with exercise both in ETT-positive patients (mean (SD) 71.4 (41.2) v 76.8 (44.0) ng/l; p<0.001) and ETT-negative patients (54.0 (61.2) v 60.1 (69.0) ng/l; p<0.001). Pre-exercise and post-exercise NT-proBNP were higher (p<0.05) in ETT-positive than in ETT-negative patients. Incremental NT-proBNP was similar in ETT-positive (4.7 (4.2) ng/l) and ETT-negative (6.2 (8.6) ng/l) patients. CONCLUSION: Serum NT-proBNP concentrations are higher in patients with exercise-induced myocardial ischaemia than in those without. Exercise-induced electrocardiographic myocardial ischaemia, however, is not associated with exaggerated BNP secretion.en
dc.language.isoenen
dc.publisherBMJ Publishingen
dc.relation.urlhttp://jcp.bmj.com/cgi/content/full/59/11/1216en
dc.subjectB-type natriuretic peptideen
dc.subjectCoronary heart diseaseen
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshElectrocardiographyen
dc.subject.meshExerciseen
dc.subject.meshExercise Testen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshMyocardial Ischemiaen
dc.subject.meshNatriuretic Peptide, Brainen
dc.titleB-type natriuretic peptide in reversible myocardial ischaemia.en
dc.typeArticleen

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