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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Diabetes, Physiology and Molecular Medicine Research Group > B-type natriuretic peptide in reversible myocardial ischaemia.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/20395
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Title: B-type natriuretic peptide in reversible myocardial ischaemia.
Authors: Chatha, K.
Alsoud, M.
Griffiths, M.J.
Elfatih, A.
Abozguia, K.
Horton, R.C.
Dunmore, Simon J.
Gama, R.
Citation: Journal of Clinical Pathology, 59(11): 1216-1217
Publisher: BMJ Publishing
Issue Date: 2006
URI: http://hdl.handle.net/2436/20395
DOI: 10.1136/jcp.2005.034702
PubMed ID: 17071810
Additional Links: http://jcp.bmj.com/cgi/content/full/59/11/1216
Abstract: BACKGROUND: Coronary heart disease is associated with increased B-type natriuretic peptides (BNPs), and, although controversial, may cause exaggerated exercise-induced BNP secretion. We investigated BNP in relation to reversible myocardial ischaemia. Materials and methods: Serum N-terminal proBNP (NT-proBNP) was measured before and after an exercise electrocardiogram test (ETT) in 14 patients with and 45 patients without exercise-induced myocardial ischaemia. Statistical analysis was carried out on logarithmically transformed data. Results, however, are pre-transformed data. RESULTS: NT-proBNP increased with exercise both in ETT-positive patients (mean (SD) 71.4 (41.2) v 76.8 (44.0) ng/l; p<0.001) and ETT-negative patients (54.0 (61.2) v 60.1 (69.0) ng/l; p<0.001). Pre-exercise and post-exercise NT-proBNP were higher (p<0.05) in ETT-positive than in ETT-negative patients. Incremental NT-proBNP was similar in ETT-positive (4.7 (4.2) ng/l) and ETT-negative (6.2 (8.6) ng/l) patients. CONCLUSION: Serum NT-proBNP concentrations are higher in patients with exercise-induced myocardial ischaemia than in those without. Exercise-induced electrocardiographic myocardial ischaemia, however, is not associated with exaggerated BNP secretion.
Type: Article
Language: en
Keywords: B-type natriuretic peptide
Coronary heart disease
MeSH: Adult
Aged
Electrocardiography
Exercise
Exercise Test
Female
Humans
Male
Middle Aged
Myocardial Ischemia
Natriuretic Peptide, Brain
ISSN: 0021-9746
Appears in Collections: Diabetes, Physiology and Molecular Medicine Research Group

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