Resistin down-regulates insulin receptor expression, and modulates cell viability in rodent pancreatic beta-cells.

2.50
Hdl Handle:
http://hdl.handle.net/2436/20394
Title:
Resistin down-regulates insulin receptor expression, and modulates cell viability in rodent pancreatic beta-cells.
Authors:
Brown, James E. P.; Onyango, David J.; Dunmore, Simon J.
Abstract:
The adipokine resistin is known to induce insulin resistance in rodent tissues. Increases in adipose tissue mass are known to have a negative effect on pancreatic beta-cell function, although the mechanisms are poorly understood. This study investigated the effects of resistin on insulin secretion, insulin receptor expression and cell viability in pancreatic beta-cells. BTC-6 or BRIN-BD11 cells were treated for 24h with resistin, and insulin receptor expression, insulin secretion and cell viability were measured. Incubation with 40ng/ml resistin caused significant decreases in insulin receptor mRNA and protein expression, but did not affect insulin secretion. At low concentrations, resistin caused significant increases in cell viability. These data implicate resistin as a factor that may regulate beta-cell function/viability, and suggests a potential mechanism by which increased adiposity causes beta-cell dysfunction.
Citation:
FEBS Letters, 581(17): 3273-3276
Publisher:
Elsevier
Issue Date:
2007
URI:
http://hdl.handle.net/2436/20394
DOI:
10.1016/j.febslet.2007.06.031
PubMed ID:
17597619
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0014579307006680
Type:
Article
Language:
en
ISSN:
0014-5793
Appears in Collections:
Diabetes, Physiology and Molecular Medicine Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorBrown, James E. P.-
dc.contributor.authorOnyango, David J.-
dc.contributor.authorDunmore, Simon J.-
dc.date.accessioned2008-03-12T10:18:35Z-
dc.date.available2008-03-12T10:18:35Z-
dc.date.issued2007-
dc.identifier.citationFEBS Letters, 581(17): 3273-3276en
dc.identifier.issn0014-5793-
dc.identifier.pmid17597619-
dc.identifier.doi10.1016/j.febslet.2007.06.031-
dc.identifier.urihttp://hdl.handle.net/2436/20394-
dc.description.abstractThe adipokine resistin is known to induce insulin resistance in rodent tissues. Increases in adipose tissue mass are known to have a negative effect on pancreatic beta-cell function, although the mechanisms are poorly understood. This study investigated the effects of resistin on insulin secretion, insulin receptor expression and cell viability in pancreatic beta-cells. BTC-6 or BRIN-BD11 cells were treated for 24h with resistin, and insulin receptor expression, insulin secretion and cell viability were measured. Incubation with 40ng/ml resistin caused significant decreases in insulin receptor mRNA and protein expression, but did not affect insulin secretion. At low concentrations, resistin caused significant increases in cell viability. These data implicate resistin as a factor that may regulate beta-cell function/viability, and suggests a potential mechanism by which increased adiposity causes beta-cell dysfunction.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0014579307006680en
dc.subjectAdipokineen
dc.subjectResistinen
dc.subjectBeta-cellen
dc.subjectInsulin receptoren
dc.subjectCell viabilityen
dc.subject.meshAnimalsen
dc.subject.meshCell Survivalen
dc.subject.meshCells, Cultureden
dc.subject.meshDose-Response Relationship, Drugen
dc.subject.meshDown-Regulationen
dc.subject.meshInsulinen
dc.subject.meshInsulin-Secreting Cellsen
dc.subject.meshMiceen
dc.subject.meshRatsen
dc.subject.meshReceptor, Insulinen
dc.subject.meshResistinen
dc.titleResistin down-regulates insulin receptor expression, and modulates cell viability in rodent pancreatic beta-cells.en
dc.typeArticleen

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