2.50
Hdl Handle:
http://hdl.handle.net/2436/17034
Title:
Movement, imaging and neurobehavioral assessment as predictors of cerebral palsy in preterm infants.
Authors:
Constantinou, Janet C.; Adamson-Macedo, Elvidina N.; Mirmiran, Majid; Fleisher, Barry E.
Abstract:
OBJECTIVE: To study the relative efficacy of three early predictors of cerebral palsy. METHOD: One Hundred and thirty infants with birth weight <1500 g were recruited. Video recordings of spontaneous general movements were made at 36 and 52 weeks postconceptional age. Magnetic resonance imaging and the neurobehavioral assessment of the preterm infant were done at 36 weeks postconceptional age. Follow-up neurological examination and Bayley assessments were made at 18 months corrected age to make early identification of cerebral palsy. RESULTS: Magnetic resonance imaging gave the best specificity and accuracy of 91 and 84% respectively. General movements at 52 weeks showed an improved specificity and accuracy over performance at 36 weeks postconceptional age. The negative predictive value for all methods tested was between 90 and 97%. Combining the results of magnetic resonance imaging and the neurobehavioral assessment improved the sensitivity of prediction to 80%, suggesting that a holistic approach to early detection of cerebral lesions is preferable to a single test. CONCLUSIONS: The majority of infants who appeared to behave within normal limits and exhibit normal brain structure in the newborn period were classified as neurologically intact at follow-up.
Citation:
Journal of Perinatology, 27(4): 225-229
Publisher:
Nature Publishing Group
Issue Date:
2007
URI:
http://hdl.handle.net/2436/17034
DOI:
10.1038/sj.jp.7211664
PubMed ID:
17304207
Additional Links:
http://www.nature.com/jp/journal/vaop/ncurrent/abs/7211664a.html;jsessionid=91997741D877160F90FCB4DAF1149C28; http://www.nature.com/index.html
Type:
Article
Language:
en
Description:
Metadata only
ISSN:
0743-8346
Appears in Collections:
Centre for Health and Social Care Improvement

Full metadata record

DC FieldValue Language
dc.contributor.authorConstantinou, Janet C.-
dc.contributor.authorAdamson-Macedo, Elvidina N.-
dc.contributor.authorMirmiran, Majid-
dc.contributor.authorFleisher, Barry E.-
dc.date.accessioned2008-01-29T15:04:58Z-
dc.date.available2008-01-29T15:04:58Z-
dc.date.issued2007-
dc.identifier.citationJournal of Perinatology, 27(4): 225-229en
dc.identifier.issn0743-8346-
dc.identifier.pmid17304207-
dc.identifier.doi10.1038/sj.jp.7211664-
dc.identifier.urihttp://hdl.handle.net/2436/17034-
dc.descriptionMetadata onlyen
dc.description.abstractOBJECTIVE: To study the relative efficacy of three early predictors of cerebral palsy. METHOD: One Hundred and thirty infants with birth weight <1500 g were recruited. Video recordings of spontaneous general movements were made at 36 and 52 weeks postconceptional age. Magnetic resonance imaging and the neurobehavioral assessment of the preterm infant were done at 36 weeks postconceptional age. Follow-up neurological examination and Bayley assessments were made at 18 months corrected age to make early identification of cerebral palsy. RESULTS: Magnetic resonance imaging gave the best specificity and accuracy of 91 and 84% respectively. General movements at 52 weeks showed an improved specificity and accuracy over performance at 36 weeks postconceptional age. The negative predictive value for all methods tested was between 90 and 97%. Combining the results of magnetic resonance imaging and the neurobehavioral assessment improved the sensitivity of prediction to 80%, suggesting that a holistic approach to early detection of cerebral lesions is preferable to a single test. CONCLUSIONS: The majority of infants who appeared to behave within normal limits and exhibit normal brain structure in the newborn period were classified as neurologically intact at follow-up.en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.urlhttp://www.nature.com/jp/journal/vaop/ncurrent/abs/7211664a.html;jsessionid=91997741D877160F90FCB4DAF1149C28en
dc.relation.urlhttp://www.nature.com/index.htmlen
dc.subject.meshCerebral Palsyen
dc.subject.meshEarly Diagnosisen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshInfanten
dc.subject.meshInfant, Newbornen
dc.subject.meshInfant, Prematureen
dc.subject.meshMagnetic Resonance Imagingen
dc.subject.meshMaleen
dc.subject.meshMovementen
dc.subject.meshPredictive Value of Testsen
dc.subject.meshRespiration, Artificialen
dc.subject.meshSensitivity and Specificityen
dc.subject.meshVideo Recordingen
dc.titleMovement, imaging and neurobehavioral assessment as predictors of cerebral palsy in preterm infants.en
dc.typeArticleen

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