Gain of 1q and loss of 22 are the most common changes detected by comparative genomic hybridisation in paediatric ependymoma.

2.50
Hdl Handle:
http://hdl.handle.net/2436/16712
Title:
Gain of 1q and loss of 22 are the most common changes detected by comparative genomic hybridisation in paediatric ependymoma.
Authors:
Ward, Samantha; Harding, Brian; Wilkins, Peter; Harkness, William; Hayward, Richard; Darling, John L.; Thomas, David G.; Warr, Tracy
Abstract:
Ependymomas are the third most common brain tumour in the paediatric population. Although cytogenetic and molecular analyses have pinpointed deletions of chromosomes 6q, 17, and 22 in a subset of tumours, definitive patterns of genetic aberrations have not been determined. In the present study, we analysed 40 ependymomas from paediatric patients for genomic loss or gain using comparative genomic hybridisation (CGH). Eighteen of the tumours (45%) had no detectable regions of imbalance. In the remaining cases, the most common copy number aberrations were loss of 22 (25% of tumours) and gain of 1q (20%). Three regions of high copy number amplification were noted at 1q24-31 (three cases), 8q21-23 (two cases), and 9p (one case). Although there was no association with the loss or gain of any chromosome arm or with benign versus anaplastic histologic characteristics, the incidence of gain of 7q and 9p and loss of 17 and 22 was significantly higher in recurrent versus primary tumours. This study has identified a number of chromosomal regions that may contain candidate genes involved in the development of different subgroups of ependymoma.
Citation:
Genes, Chromosomes and Cancer, 32(1): 59-66
Publisher:
Wiley Interscience
Issue Date:
2001
URI:
http://hdl.handle.net/2436/16712
DOI:
10.1002/gcc.1167
PubMed ID:
11477662
Additional Links:
http://www3.interscience.wiley.com/cgi-bin/abstract/84503984/
Type:
Article
Language:
en
Description:
Metadata only
ISSN:
1045-2257
Appears in Collections:
Cancer Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorWard, Samantha-
dc.contributor.authorHarding, Brian-
dc.contributor.authorWilkins, Peter-
dc.contributor.authorHarkness, William-
dc.contributor.authorHayward, Richard-
dc.contributor.authorDarling, John L.-
dc.contributor.authorThomas, David G.-
dc.contributor.authorWarr, Tracy-
dc.date.accessioned2008-01-23T14:27:51Z-
dc.date.available2008-01-23T14:27:51Z-
dc.date.issued2001-
dc.identifier.citationGenes, Chromosomes and Cancer, 32(1): 59-66en
dc.identifier.issn1045-2257-
dc.identifier.pmid11477662-
dc.identifier.doi10.1002/gcc.1167-
dc.identifier.urihttp://hdl.handle.net/2436/16712-
dc.descriptionMetadata onlyen
dc.description.abstractEpendymomas are the third most common brain tumour in the paediatric population. Although cytogenetic and molecular analyses have pinpointed deletions of chromosomes 6q, 17, and 22 in a subset of tumours, definitive patterns of genetic aberrations have not been determined. In the present study, we analysed 40 ependymomas from paediatric patients for genomic loss or gain using comparative genomic hybridisation (CGH). Eighteen of the tumours (45%) had no detectable regions of imbalance. In the remaining cases, the most common copy number aberrations were loss of 22 (25% of tumours) and gain of 1q (20%). Three regions of high copy number amplification were noted at 1q24-31 (three cases), 8q21-23 (two cases), and 9p (one case). Although there was no association with the loss or gain of any chromosome arm or with benign versus anaplastic histologic characteristics, the incidence of gain of 7q and 9p and loss of 17 and 22 was significantly higher in recurrent versus primary tumours. This study has identified a number of chromosomal regions that may contain candidate genes involved in the development of different subgroups of ependymoma.en
dc.language.isoenen
dc.publisherWiley Interscienceen
dc.relation.urlhttp://www3.interscience.wiley.com/cgi-bin/abstract/84503984/en
dc.subject.meshAdolescenten
dc.subject.meshAllelic Imbalanceen
dc.subject.meshBrain Neoplasmsen
dc.subject.meshChildrenen
dc.subject.meshChild, Preschoolen
dc.subject.meshChromosomes, Human, Pair 1en
dc.subject.meshChromosomes, Human, Pair 22en
dc.subject.meshEpendymomaen
dc.subject.meshFemaleen
dc.subject.meshGene Amplificationen
dc.subject.meshHumansen
dc.subject.meshInfanten
dc.subject.meshLoss of Heterozygosityen
dc.subject.meshMaleen
dc.subject.meshNeoplasm Recurrence, Localen
dc.subject.meshNucleic Acid Hybridizationen
dc.subject.meshSupratentorial Neoplasmsen
dc.subject.meshTumor Cells, Cultureden
dc.titleGain of 1q and loss of 22 are the most common changes detected by comparative genomic hybridisation in paediatric ependymoma.en
dc.typeArticleen

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