Identification of extensive genomic loss and gain by comparative genomic hybridisation in malignant astrocytoma in children and young adults.

2.50
Hdl Handle:
http://hdl.handle.net/2436/16694
Title:
Identification of extensive genomic loss and gain by comparative genomic hybridisation in malignant astrocytoma in children and young adults.
Authors:
Warr, Tracy; Ward, Samantha; Burrows, J.; Harding, Brian; Wilkins, Peter; Harkness, William; Hayward, Richard; Darling, John L.; Thomas, David G.
Abstract:
Although astrocytomas are the most common central nervous system tumours in all age groups, there is substantial evidence that tumours arising in young patients (< 25 years of age) do not have the same genetic abnormalities that are characteristic of tumours in older patients. Furthermore, novel, consistent changes have not been identified in astrocytomas in children and young adults. We analysed 13 malignant astrocytomas from young patients using comparative genomic hybridisation. Regions of genomic imbalance were identified in 10 cases. The most common recurrent copy number aberrations were loss of 16p (54% of cases), 17p (38%), 19p (38%), and 22 (38%) and gain on 2q (38%), 12q (38%), 13 (38%), 4q (31%), 5q (31%), and 8q (31%). Seven regions of high copy number amplification were observed at 8q21-22 (three cases), 7q22-23 (two cases), and 1p21-22, 2q22, 12q13-pter, 12q15-21, and 13q11-14 (one case each). This study provides evidence of new characteristic chromosomal imbalances from which potential candidate genes involved in the development of malignant astrocytoma in children and young adults may be identified.
Citation:
Genes, Chromosomes and Cancer, 31(1): 15-22
Publisher:
Wiley Interscience
Issue Date:
2001
URI:
http://hdl.handle.net/2436/16694
DOI:
10.1002/gcc.1113
PubMed ID:
11284031
Additional Links:
http://www3.interscience.wiley.com/cgi-bin/abstract/77005859/
Language:
en
Description:
Metadata only
ISSN:
1045-2257
Appears in Collections:
Cancer Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorWarr, Tracy-
dc.contributor.authorWard, Samantha-
dc.contributor.authorBurrows, J.-
dc.contributor.authorHarding, Brian-
dc.contributor.authorWilkins, Peter-
dc.contributor.authorHarkness, William-
dc.contributor.authorHayward, Richard-
dc.contributor.authorDarling, John L.-
dc.contributor.authorThomas, David G.-
dc.date.accessioned2008-01-23T14:48:17Z-
dc.date.available2008-01-23T14:48:17Z-
dc.date.issued2001-
dc.identifier.citationGenes, Chromosomes and Cancer, 31(1): 15-22en
dc.identifier.issn1045-2257-
dc.identifier.pmid11284031-
dc.identifier.doi10.1002/gcc.1113-
dc.identifier.urihttp://hdl.handle.net/2436/16694-
dc.descriptionMetadata onlyen
dc.description.abstractAlthough astrocytomas are the most common central nervous system tumours in all age groups, there is substantial evidence that tumours arising in young patients (< 25 years of age) do not have the same genetic abnormalities that are characteristic of tumours in older patients. Furthermore, novel, consistent changes have not been identified in astrocytomas in children and young adults. We analysed 13 malignant astrocytomas from young patients using comparative genomic hybridisation. Regions of genomic imbalance were identified in 10 cases. The most common recurrent copy number aberrations were loss of 16p (54% of cases), 17p (38%), 19p (38%), and 22 (38%) and gain on 2q (38%), 12q (38%), 13 (38%), 4q (31%), 5q (31%), and 8q (31%). Seven regions of high copy number amplification were observed at 8q21-22 (three cases), 7q22-23 (two cases), and 1p21-22, 2q22, 12q13-pter, 12q15-21, and 13q11-14 (one case each). This study provides evidence of new characteristic chromosomal imbalances from which potential candidate genes involved in the development of malignant astrocytoma in children and young adults may be identified.en
dc.language.isoenen
dc.publisherWiley Interscienceen
dc.relation.urlhttp://www3.interscience.wiley.com/cgi-bin/abstract/77005859/en
dc.subjectYoung adults-
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAstrocytomaen
dc.subject.meshCentral Nervous System Neoplasmsen
dc.subject.meshChildrenen
dc.subject.meshChild, Preschoolen
dc.subject.meshChromosomal Aberrationsen
dc.subject.meshChromosome Disordersen
dc.subject.meshFemaleen
dc.subject.meshGene Amplificationen
dc.subject.meshGene Dosageen
dc.subject.meshHumansen
dc.subject.meshIn Situ Hybridizationen
dc.subject.meshMaleen
dc.subject.meshSequence Deletionen
dc.titleIdentification of extensive genomic loss and gain by comparative genomic hybridisation in malignant astrocytoma in children and young adults.en

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