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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Pharmacy and Natural Products Research Group > The effects of a Chinese medicinal suppository (Vitalliver) on insulin-like growth factor 1 and homocysteine in patients with hepatitis B infection.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/15834
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Title: The effects of a Chinese medicinal suppository (Vitalliver) on insulin-like growth factor 1 and homocysteine in patients with hepatitis B infection.
Authors: Chui, Siu-Hon
Chan, Kelvin C.
Chui, Albert K. K.
Shek, L.S.
Wong, Ricky N. S.
Citation: Phytotherapy Research, 19(8): 674-678
Publisher: Wiley InterScience
Issue Date: 2005
URI: http://hdl.handle.net/2436/15834
DOI: 10.1002/ptr.1726
PubMed ID: 16177969
Additional Links: http://www3.interscience.wiley.com/journal/112094128/abstract
Abstract: The liver is the major organ for the metabolism of homocysteine (Hcy) and production of insulin-like growth factor 1 (IGF-1). Hcy metabolism and IGF-1 synthesis may be impaired in chronic liver diseases. The study investigated the regulatory effect of a Chinese herbal suppository, Vitalliver, on Hcy and IGF-1, as well as their relationship in patients with hepatitis B infection. Forty patients with chronic hepatitis B virus (HBV) infection without cirrhosis, 25 males and 15 females, were observed for changes in Hcy and IGF-1 after the administration of Vitalliver (one nightly) for a period of 3 months. Serum levels of Hcy, IGF-1 and IGFBP-3 were measured at baseline, and at 1 month and 3 months after treatment. Vitalliver reduced Hcy levels significantly (p = 0.001) from 9.7 +/- 2.8 to 9.0 +/- 2.1 micromol/L after treatment of 3 months. Furthermore, the IGF-1 levels increased significantly (p < 0.001) from 170.2 +/- 81.8 to 212.8 +/- 80.9 ng/mL at 1 month and 187.5 +/- 72.3 ng/mL at 3 months (p = 0.001) after treatment. In conclusion, it is speculated Vitalliver may have a self-regulatory effect on the release of IGF-1 in HBV patients without liver cirrhosis.
Type: Article
Language: en
Description: Metadata only
Keywords: Homocysteine
Vitalliver
Hepatitis B
ISSN: 0951-418X
Appears in Collections: Pharmacy and Natural Products Research Group

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