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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Molecular Pharmacology Research Group > Amoebae promote persistence of epidemic strains of MRSA.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/15814
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Title: Amoebae promote persistence of epidemic strains of MRSA.
Authors: Huws, Sharon A.
Smith, Anthony W.
Enright, Mark C.
Wood, Pauline J.
Brown, Michael R. W.
Citation: Environmental Microbiology, 8(6): 1130-1133
Publisher: Wiley InterScience
Issue Date: 2006
URI: http://hdl.handle.net/2436/15814
DOI: 10.1111/j.1462-2920.2006.00991.x
PubMed ID: 16689734
Additional Links: http://www3.interscience.wiley.com/journal/118567427/abstract
Abstract: The control of healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA) infection is of concern worldwide. Given the evidence that several pathogenic species replicate within amoebae and emerge more virulent and more resistant and the abundance of amoebae in healthcare settings, we investigated interactions of Acanthamoeba polyphaga with epidemic MRSA isolates. MRSA proliferated in the presence of amoebae, attributable partly to intracellular replication. Following 24 h of co-culture, confocal microscopy revealed that c. 50% amoebae had viable MRSA within phago-lysosomes and 2% of amoebae were heavily infected with viable cocci throughout the cytoplasm. Infection control strategies should recognize the contribution of protozoa.
Type: Article
Language: en
Keywords: Amoebae
Epidemic strains
MRSA
Healthcare
ISSN: 1462-2912
Appears in Collections: Molecular Pharmacology Research Group

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