2.50
Hdl Handle:
http://hdl.handle.net/2436/15814
Title:
Amoebae promote persistence of epidemic strains of MRSA.
Authors:
Huws, Sharon A.; Smith, Anthony W.; Enright, Mark C.; Wood, Pauline J.; Brown, Michael R. W.
Abstract:
The control of healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA) infection is of concern worldwide. Given the evidence that several pathogenic species replicate within amoebae and emerge more virulent and more resistant and the abundance of amoebae in healthcare settings, we investigated interactions of Acanthamoeba polyphaga with epidemic MRSA isolates. MRSA proliferated in the presence of amoebae, attributable partly to intracellular replication. Following 24 h of co-culture, confocal microscopy revealed that c. 50% amoebae had viable MRSA within phago-lysosomes and 2% of amoebae were heavily infected with viable cocci throughout the cytoplasm. Infection control strategies should recognize the contribution of protozoa.
Citation:
Environmental Microbiology, 8(6): 1130-1133
Publisher:
Wiley InterScience
Issue Date:
2006
URI:
http://hdl.handle.net/2436/15814
DOI:
10.1111/j.1462-2920.2006.00991.x
PubMed ID:
16689734
Additional Links:
http://www3.interscience.wiley.com/journal/118567427/abstract
Type:
Article
Language:
en
ISSN:
1462-2912
Appears in Collections:
Molecular Pharmacology Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorHuws, Sharon A.-
dc.contributor.authorSmith, Anthony W.-
dc.contributor.authorEnright, Mark C.-
dc.contributor.authorWood, Pauline J.-
dc.contributor.authorBrown, Michael R. W.-
dc.date.accessioned2008-01-08T11:52:20Z-
dc.date.available2008-01-08T11:52:20Z-
dc.date.issued2006-
dc.identifier.citationEnvironmental Microbiology, 8(6): 1130-1133en
dc.identifier.issn1462-2912-
dc.identifier.pmid16689734-
dc.identifier.doi10.1111/j.1462-2920.2006.00991.x-
dc.identifier.urihttp://hdl.handle.net/2436/15814-
dc.description.abstractThe control of healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA) infection is of concern worldwide. Given the evidence that several pathogenic species replicate within amoebae and emerge more virulent and more resistant and the abundance of amoebae in healthcare settings, we investigated interactions of Acanthamoeba polyphaga with epidemic MRSA isolates. MRSA proliferated in the presence of amoebae, attributable partly to intracellular replication. Following 24 h of co-culture, confocal microscopy revealed that c. 50% amoebae had viable MRSA within phago-lysosomes and 2% of amoebae were heavily infected with viable cocci throughout the cytoplasm. Infection control strategies should recognize the contribution of protozoa.en
dc.language.isoenen
dc.publisherWiley InterScienceen
dc.relation.urlhttp://www3.interscience.wiley.com/journal/118567427/abstracten
dc.subjectAmoebaeen
dc.subjectEpidemic strainsen
dc.subjectMRSAen
dc.subjectHealthcareen
dc.titleAmoebae promote persistence of epidemic strains of MRSA.en
dc.typeArticleen

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