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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Cancer Research Group > Structural, biochemical and electrostatic basis of serotype specificity in bovine enteroviruses

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/15444
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Title: Structural, biochemical and electrostatic basis of serotype specificity in bovine enteroviruses
Authors: Smyth, M.S.
Martin, Jan H.
Citation: Archives of Virology, 146(2): 347-355
Publisher: Springer Wien
Issue Date: 2001
URI: http://hdl.handle.net/2436/15444
DOI: 10.1007/s007050170179
Additional Links: http://www.springerlink.com/content/2c9a2pr4m7wmpfpf/
Abstract: We have performed immunostructural analyses of three closely related picornaviruses in order to gain understanding of the biochemical and structural basis of serotype specificity. We carried out sequence alignments of the capsid regions of three bovine enterovirus strains: VG-5-27 and M-4 from serotype 1 and PS-87 from serotype 2. Using our knowledge of the three dimensional and antigenic structure of strain VG-5-27 and the high levels of sequence identity between the strains, we have calculated the structures and solvent-accessible electrostatic potentials of the epitopes of all three viruses. We have demonstrated the viability of the molecular models of the epitopes of the M-4 and PS-87 strains. In each of the strains, we have explained the serotype specificities in terms of specific physical and chemical properties, and identified individual residues which are pivotal in determination of antibody recognition. These changes are in agreement with the known cross-reactivity of peptide and antiviral sera, showing that it is possible to derive structures for short variable sections of proteins of high sequence identity using molecular modelling which are significant in terms of biological function. We believe this study to be a novel approach in the analysis of virus serotype specificity.
Type: Article
Language: en
Description: Metadata only.
Keywords: Serotype specificity
Bovine enteroviruses
Picornaviruses
VG-5-27
Animal viruses
ISSN: 03048608,14328798
Appears in Collections: Cancer Research Group

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