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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Molecular Pharmacology Research Group > Novel mastoparan analogs induce differential secretion from mast cells.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/14646
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Title: Novel mastoparan analogs induce differential secretion from mast cells.
Authors: Farquhar, Michelle
Soomets, Ursel
Bates, Ruth L.
Martin, Ashley
Langel, Ulo
Howl, John D.
Citation: Chemistry & Biology, 9(1): 63-70
Publisher: Elsevier Science B.V
Issue Date: 2002
URI: http://hdl.handle.net/2436/14646
DOI: 10.1016/S1074-5521(01)00098-9
Additional Links: http://www.ingentaconnect.com/content/els/10745521/2002/00000009/00000001/art00098
http://direct.bl.uk/bld/PlaceOrder.do?UIN=108952570&ETOC=RN&from=searchengine
Abstract: Cationic amphiphilic peptides stimulate secretion via a receptor-independent action upon G proteins. We have previously utilized chimeric analogs of mastoparan (MP), including galparan (galanin(1-13)-MP ), as molecular probes of secretion. Here, we further resolve the structure-activity relationship of peptidyl secretagogs, including rationally designed chimeric MP analogs. The secretory efficacies of 10 MP analogs were significantly higher than 45 unrelated basic peptides. Comparative studies identified MP analogs that are differential secretagogs for 5-hydroxytryptamine (5-HT) and beta-hexosaminidase. Peptide-induced activation of phospholipase D (PLD), an enzyme intimately involved in regulated exocytosis [5], correlated with the secretion of beta-hexosaminidase but not 5-HT. Thus, these data indicate that different mechanisms are responsible for the exocytosis of 5-HT and beta-hexosaminidase, respectively. Moreover, mastoparan analogs are novel tools for probing the molecular details of exocytosis and other biological phenomena.
Type: Article
Language: en
Description: Metadata only
Keywords: Novel mastoparan analogs
Differential secretion
Mast Cells
Peptides
ISSN: 10745521
Appears in Collections: Molecular Pharmacology Research Group

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