Inhibition of prostaglandin synthesis does not alter the decrease in pre-capillary resistance in the human calf in response to small cumulative increases in venous congestion

2.50
Hdl Handle:
http://hdl.handle.net/2436/14625
Title:
Inhibition of prostaglandin synthesis does not alter the decrease in pre-capillary resistance in the human calf in response to small cumulative increases in venous congestion
Authors:
Anderson, Stephen I.; Brown, Margaret D.
Abstract:
The decrease in pre-capillary resistance in the human calf during gradual cumulative increases in venous congestion pressure has been proposed to represent vasodilator signalling between the venous and arterial microcirculations. The present study investigated whether prostaglandins are involved in this local flow regulation by measuring calf blood flow and microvascular filtration capacity using strain gauge plethysmography in young male subjects before (baseline) and after taking either ibuprofen, an inhibitor of prostaglandin synthesis (1600 mg over 2 days), or placebo. At baseline, inflation of a thigh cuff to 50 mmHg in steps of 10 mmHg, each held for 5 min, did not decrease arterial inflow, confirming a reduction of pre-capillary resistance. Ibuprofen reduced resting calf blood flow by 35% (P<0.001), but flow at a Pcuff (cuff pressure) of 50 mmHg was 97% of this value, i.e. pre-capillary resistance had decreased to the same extent as before inhibition of prostaglandin synthesis. Ibuprofen also reduced microvascular filtration capacity (2.98±1.20 compared with 3.71±0.89 ml·min-1·100 ml-1·mmHg-1×10-3; P<0.05), probably due to a combination of reduced arterial inflow and lower venous pressure (8.5±5.2 compared with 12.6±2.8 mmHg; P<0.05) that moderated capillary hydrostatic pressure to override direct effects of inhibition of prostaglandin synthesis on permeability. Placebo was without effect on any measurement. It is unlikely therefore that prostaglandin-mediated vasodilator signals, which have been demonstrated between paired veins and arteries, are important in local vasodilation in response to venous congestion.
Citation:
Clinical Science, 109(3): 303-309
Publisher:
Portland Press
Issue Date:
2005
URI:
http://hdl.handle.net/2436/14625
DOI:
10.1042/CS20050113
PubMed ID:
15898957
Additional Links:
http://www.portlandpress.com/pp/default.htm; http://www.clinsci.org/default.htm
Type:
Article
Language:
en
Description:
Metadata only
ISSN:
01435221,14708736
Appears in Collections:
Diabetes, Physiology and Molecular Medicine Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorAnderson, Stephen I.-
dc.contributor.authorBrown, Margaret D.-
dc.date.accessioned2007-11-19T13:10:05Z-
dc.date.available2007-11-19T13:10:05Z-
dc.date.issued2005-
dc.identifier.citationClinical Science, 109(3): 303-309en
dc.identifier.issn01435221,14708736-
dc.identifier.pmid15898957-
dc.identifier.doi10.1042/CS20050113-
dc.identifier.urihttp://hdl.handle.net/2436/14625-
dc.descriptionMetadata onlyen
dc.description.abstractThe decrease in pre-capillary resistance in the human calf during gradual cumulative increases in venous congestion pressure has been proposed to represent vasodilator signalling between the venous and arterial microcirculations. The present study investigated whether prostaglandins are involved in this local flow regulation by measuring calf blood flow and microvascular filtration capacity using strain gauge plethysmography in young male subjects before (baseline) and after taking either ibuprofen, an inhibitor of prostaglandin synthesis (1600 mg over 2 days), or placebo. At baseline, inflation of a thigh cuff to 50 mmHg in steps of 10 mmHg, each held for 5 min, did not decrease arterial inflow, confirming a reduction of pre-capillary resistance. Ibuprofen reduced resting calf blood flow by 35% (P<0.001), but flow at a Pcuff (cuff pressure) of 50 mmHg was 97% of this value, i.e. pre-capillary resistance had decreased to the same extent as before inhibition of prostaglandin synthesis. Ibuprofen also reduced microvascular filtration capacity (2.98±1.20 compared with 3.71±0.89 ml·min-1·100 ml-1·mmHg-1×10-3; P<0.05), probably due to a combination of reduced arterial inflow and lower venous pressure (8.5±5.2 compared with 12.6±2.8 mmHg; P<0.05) that moderated capillary hydrostatic pressure to override direct effects of inhibition of prostaglandin synthesis on permeability. Placebo was without effect on any measurement. It is unlikely therefore that prostaglandin-mediated vasodilator signals, which have been demonstrated between paired veins and arteries, are important in local vasodilation in response to venous congestion.en
dc.format.extent190919 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.publisherPortland Pressen
dc.relation.urlhttp://www.portlandpress.com/pp/default.htmen
dc.relation.urlhttp://www.clinsci.org/default.htmen
dc.subjectCalf blood flowen
dc.subjectPaired veni-arteriolar signallingen
dc.subjectPre-capillary resistanceen
dc.subjectProstaglandinen
dc.titleInhibition of prostaglandin synthesis does not alter the decrease in pre-capillary resistance in the human calf in response to small cumulative increases in venous congestionen
dc.typeArticleen
dc.format.digYES-
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