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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Sport, Exercise and Health Research Group > Evidence for consistency of the glycation gap in diabetes.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/135884
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Title: Evidence for consistency of the glycation gap in diabetes.
Authors: Nayak, Ananth U.
Holland, Martin R.
Macdonald, David R.
Nevill, Alan M.
Singh, Baldev M.
Citation: Diabetes Care
Publisher: American Diabetes Association
Journal: Diabetes care
Issue Date: 2011
URI: http://hdl.handle.net/2436/135884
DOI: 10.2337/dc10-1767
PubMed ID: 21715524
Abstract: OBJECTIVE Discordance between HbA(1c) and fructosamine estimations in the assessment of glycemia is often encountered. A number of mechanisms might explain such discordance, but whether it is consistent is uncertain. This study aims to coanalyze paired glycosylated hemoglobin (HbA(1c))-fructosamine estimations by using fructosamine to determine a predicted HbA(1c), to calculate a glycation gap (G-gap) and to determine whether the G-gap is consistent over time. RESEARCH DESIGN AND METHODS We included 2,263 individuals with diabetes who had at least two paired HbA(1c)-fructosamine estimations that were separated by 10 ± 8 months. Of these, 1,217 individuals had a third pair. The G-gap was calculated as G-gap = HbA(1c) minus the standardized fructosamine-derived HbA(1c) equivalent (FHbA(1c)). The hypothesis that the G-gap would remain consistent in individuals over time was tested. RESULTS The G-gaps were similar in the first, second, and third paired samples (0.0 ± 1.2, 0.0 ± 1.3, and 0.0 ± 1.3, respectively). Despite significant changes in the HbA(1c) and fructosamine, the G-gap did not differ in absolute or relative terms and showed no significant within subject variability. The direction of the G-gap remained consistent. CONCLUSIONS The G-gap appears consistent over time; thus, by inference any key underlying mechanisms are likely to be consistent. G-gap calculation may be a method of exploring and evaluating any such underlying mechanisms.
Type: Article
Language: en
Description: Epub ahead of print
ISSN: 1935-5548
Appears in Collections: Sport, Exercise and Health Research Group

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