2.50
Hdl Handle:
http://hdl.handle.net/2436/135884
Title:
Evidence for consistency of the glycation gap in diabetes.
Authors:
Nayak, Ananth U.; Holland, Martin R.; Macdonald, David R.; Nevill, Alan M.; Singh, Baldev M.
Abstract:
OBJECTIVE Discordance between HbA(1c) and fructosamine estimations in the assessment of glycemia is often encountered. A number of mechanisms might explain such discordance, but whether it is consistent is uncertain. This study aims to coanalyze paired glycosylated hemoglobin (HbA(1c))-fructosamine estimations by using fructosamine to determine a predicted HbA(1c), to calculate a glycation gap (G-gap) and to determine whether the G-gap is consistent over time. RESEARCH DESIGN AND METHODS We included 2,263 individuals with diabetes who had at least two paired HbA(1c)-fructosamine estimations that were separated by 10 ± 8 months. Of these, 1,217 individuals had a third pair. The G-gap was calculated as G-gap = HbA(1c) minus the standardized fructosamine-derived HbA(1c) equivalent (FHbA(1c)). The hypothesis that the G-gap would remain consistent in individuals over time was tested. RESULTS The G-gaps were similar in the first, second, and third paired samples (0.0 ± 1.2, 0.0 ± 1.3, and 0.0 ± 1.3, respectively). Despite significant changes in the HbA(1c) and fructosamine, the G-gap did not differ in absolute or relative terms and showed no significant within subject variability. The direction of the G-gap remained consistent. CONCLUSIONS The G-gap appears consistent over time; thus, by inference any key underlying mechanisms are likely to be consistent. G-gap calculation may be a method of exploring and evaluating any such underlying mechanisms.
Citation:
Diabetes Care
Publisher:
American Diabetes Association
Journal:
Diabetes care
Issue Date:
2011
URI:
http://hdl.handle.net/2436/135884
DOI:
10.2337/dc10-1767
PubMed ID:
21715524
Type:
Article
Language:
en
Description:
Epub ahead of print
ISSN:
1935-5548
Appears in Collections:
Sport, Exercise and Health Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorNayak, Ananth U.en
dc.contributor.authorHolland, Martin R.en
dc.contributor.authorMacdonald, David R.en
dc.contributor.authorNevill, Alan M.en
dc.contributor.authorSingh, Baldev M.en
dc.date.accessioned2011-07-12T13:51:14Z-
dc.date.available2011-07-12T13:51:14Z-
dc.date.issued2011-
dc.identifier.citationDiabetes Careen
dc.identifier.issn1935-5548-
dc.identifier.pmid21715524-
dc.identifier.doi10.2337/dc10-1767-
dc.identifier.urihttp://hdl.handle.net/2436/135884-
dc.descriptionEpub ahead of printen
dc.description.abstractOBJECTIVE Discordance between HbA(1c) and fructosamine estimations in the assessment of glycemia is often encountered. A number of mechanisms might explain such discordance, but whether it is consistent is uncertain. This study aims to coanalyze paired glycosylated hemoglobin (HbA(1c))-fructosamine estimations by using fructosamine to determine a predicted HbA(1c), to calculate a glycation gap (G-gap) and to determine whether the G-gap is consistent over time. RESEARCH DESIGN AND METHODS We included 2,263 individuals with diabetes who had at least two paired HbA(1c)-fructosamine estimations that were separated by 10 ± 8 months. Of these, 1,217 individuals had a third pair. The G-gap was calculated as G-gap = HbA(1c) minus the standardized fructosamine-derived HbA(1c) equivalent (FHbA(1c)). The hypothesis that the G-gap would remain consistent in individuals over time was tested. RESULTS The G-gaps were similar in the first, second, and third paired samples (0.0 ± 1.2, 0.0 ± 1.3, and 0.0 ± 1.3, respectively). Despite significant changes in the HbA(1c) and fructosamine, the G-gap did not differ in absolute or relative terms and showed no significant within subject variability. The direction of the G-gap remained consistent. CONCLUSIONS The G-gap appears consistent over time; thus, by inference any key underlying mechanisms are likely to be consistent. G-gap calculation may be a method of exploring and evaluating any such underlying mechanisms.en
dc.languageENG-
dc.language.isoenen
dc.publisherAmerican Diabetes Associationen
dc.titleEvidence for consistency of the glycation gap in diabetes.en
dc.typeArticleen
dc.identifier.journalDiabetes careen

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