Immediate and short-term consequences of secondhand smoke exposure on the respiratory system.

2.50
Hdl Handle:
http://hdl.handle.net/2436/129495
Title:
Immediate and short-term consequences of secondhand smoke exposure on the respiratory system.
Authors:
Flouris, Andreas D.; Koutedakis, Yiannis
Abstract:
Purpose of review This review critically evaluates the existing biological evidence regarding the immediate and short-term respiratory consequences of secondhand smoke (SHS). Recent findings A 1-h exposure to SHS at bar/restaurant levels generates a marked inflammatory reaction and significant decrements on lung function. These deleterious effects of SHS are exacerbated when physical activity follows the SHS exposure, particularly in less fit individuals. The main respiratory effect mechanisms of SHS include a direct induction of growth factors resulting in airway remodelling and alterations in nitric oxide regulation. Pharmacological agents that increase either apical membrane chloride conductance or basolateral membrane potassium conductance may be of therapeutic benefit in patients with diseases related to SHS exposure. Moreover, treatment with statins has shown beneficial effects towards preventing the SHS-induced pulmonary hypertension, vascular remodelling, and endothelial dysfunction. Summary Based on recently discovered evidence, even brief and short-term exposures to SHS generate significant adverse effects on the human respiratory system. Future research directions in this area include the concentrations of tobacco smoke constituents in the alveolar milieu following SHS exposure, individual susceptibility to SHS, as well as pharmacological treatments for reversing the SHS-induced airway remodelling.
Citation:
Current opinion in pulmonary medicine, 17(2):110-5
Publisher:
Lippincott Williams & Wilkins
Journal:
Current opinion in pulmonary medicine
Issue Date:
2011
URI:
http://hdl.handle.net/2436/129495
DOI:
10.1097/MCP.0b013e328343165d
PubMed ID:
21178628
Type:
Article
Language:
en
ISSN:
1070-5287
Appears in Collections:
Sport, Exercise and Health Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorFlouris, Andreas D.en
dc.contributor.authorKoutedakis, Yiannisen
dc.date.accessioned2011-05-13T11:08:21Z-
dc.date.available2011-05-13T11:08:21Z-
dc.date.issued2011-
dc.identifier.citationCurrent opinion in pulmonary medicine, 17(2):110-5en
dc.identifier.issn1070-5287-
dc.identifier.pmid21178628-
dc.identifier.doi10.1097/MCP.0b013e328343165d-
dc.identifier.urihttp://hdl.handle.net/2436/129495-
dc.description.abstractPurpose of review This review critically evaluates the existing biological evidence regarding the immediate and short-term respiratory consequences of secondhand smoke (SHS). Recent findings A 1-h exposure to SHS at bar/restaurant levels generates a marked inflammatory reaction and significant decrements on lung function. These deleterious effects of SHS are exacerbated when physical activity follows the SHS exposure, particularly in less fit individuals. The main respiratory effect mechanisms of SHS include a direct induction of growth factors resulting in airway remodelling and alterations in nitric oxide regulation. Pharmacological agents that increase either apical membrane chloride conductance or basolateral membrane potassium conductance may be of therapeutic benefit in patients with diseases related to SHS exposure. Moreover, treatment with statins has shown beneficial effects towards preventing the SHS-induced pulmonary hypertension, vascular remodelling, and endothelial dysfunction. Summary Based on recently discovered evidence, even brief and short-term exposures to SHS generate significant adverse effects on the human respiratory system. Future research directions in this area include the concentrations of tobacco smoke constituents in the alveolar milieu following SHS exposure, individual susceptibility to SHS, as well as pharmacological treatments for reversing the SHS-induced airway remodelling.en
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen
dc.subjectAirway remodelingen
dc.subjectEnvironmental tobacco smoke,en
dc.subjectInflammationen
dc.subjectPassive smokingen
dc.subjectRespiratory diseaseen
dc.subject.meshAirway Remodelingen
dc.subject.meshHumansen
dc.subject.meshInflammationen
dc.subject.meshInhalation Exposureen
dc.subject.meshMotor Activityen
dc.subject.meshOxidative Stressen
dc.subject.meshRespiratory Systemen
dc.subject.meshRespiratory Tract Diseasesen
dc.subject.meshRisk Factorsen
dc.subject.meshTime Factorsen
dc.subject.meshTobacco Smoke Pollutionen
dc.titleImmediate and short-term consequences of secondhand smoke exposure on the respiratory system.en
dc.typeArticleen
dc.identifier.journalCurrent opinion in pulmonary medicineen

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