2.50
Hdl Handle:
http://hdl.handle.net/2436/117150
Title:
Eukaryote polyphosphate kinases: is the 'Kornberg' complex ubiquitous?
Authors:
Hooley, Paul; Whitehead, Michael P.; Brown, Michael R. W.
Abstract:
Polyphosphate (poly P) is a polymer of up to several hundred phosphate residues and is important to a variety of cell processes. The main poly P synthetic enzyme in many bacteria is poly P kinase 1 (PPK1), which until recently had been detected among eukaryotes in some protists only. There is now evidence for the presence in several other eukaryotes of PPK1 homologues and also a second bacteria-type enzyme, PPK2. The latest genome databases reveal that the 'Kornberg' enzyme complex of three actin-related proteins, termed DdPPK2 in Dictyostelium discoideum, might also be ubiquitous in eukaryotes. Owing to the intimate association of poly P synthesis with the formation of structural fibres, this ubiquity indicates a central role for this molecule in the evolution of eukaryotic cells.
Citation:
Trends in biochemical sciences, 33 (12):577-82
Publisher:
Elsevier
Journal:
Trends in biochemical sciences
Issue Date:
2008
URI:
http://hdl.handle.net/2436/117150
DOI:
10.1016/j.tibs.2008.09.007
PubMed ID:
18938082
Type:
Article
Language:
en
ISSN:
0968-0004
Appears in Collections:
Applied Microbiology Research Group; Cancer Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorHooley, Paulen
dc.contributor.authorWhitehead, Michael P.en
dc.contributor.authorBrown, Michael R. W.en
dc.date.accessioned2010-12-03T16:06:43Z-
dc.date.available2010-12-03T16:06:43Z-
dc.date.issued2008-
dc.identifier.citationTrends in biochemical sciences, 33 (12):577-82en
dc.identifier.issn0968-0004-
dc.identifier.pmid18938082-
dc.identifier.doi10.1016/j.tibs.2008.09.007-
dc.identifier.urihttp://hdl.handle.net/2436/117150-
dc.description.abstractPolyphosphate (poly P) is a polymer of up to several hundred phosphate residues and is important to a variety of cell processes. The main poly P synthetic enzyme in many bacteria is poly P kinase 1 (PPK1), which until recently had been detected among eukaryotes in some protists only. There is now evidence for the presence in several other eukaryotes of PPK1 homologues and also a second bacteria-type enzyme, PPK2. The latest genome databases reveal that the 'Kornberg' enzyme complex of three actin-related proteins, termed DdPPK2 in Dictyostelium discoideum, might also be ubiquitous in eukaryotes. Owing to the intimate association of poly P synthesis with the formation of structural fibres, this ubiquity indicates a central role for this molecule in the evolution of eukaryotic cells.en
dc.language.isoenen
dc.publisherElsevieren
dc.subject.meshActinsen
dc.subject.meshAmino Acid Sequenceen
dc.subject.meshAnimalsen
dc.subject.meshBacteriaen
dc.subject.meshComputational Biologyen
dc.subject.meshDictyosteliumen
dc.subject.meshDrug Designen
dc.subject.meshEukaryotic Cellsen
dc.subject.meshFungal Proteinsen
dc.subject.meshMolecular Sequence Dataen
dc.subject.meshMultienzyme Complexesen
dc.subject.meshPhosphotransferases (Phosphate Group Acceptor)en
dc.subject.meshPolyphosphatesen
dc.subject.meshSequence Alignmenten
dc.titleEukaryote polyphosphate kinases: is the 'Kornberg' complex ubiquitous?en
dc.typeArticleen
dc.identifier.journalTrends in biochemical sciencesen

Related articles on PubMed

All Items in WIRE are protected by copyright, with all rights reserved, unless otherwise indicated.