Eukaryote polyphosphate kinases: is the 'Kornberg' complex ubiquitous?
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Abstract
Polyphosphate (poly P) is a polymer of up to several hundred phosphate residues and is important to a variety of cell processes. The main poly P synthetic enzyme in many bacteria is poly P kinase 1 (PPK1), which until recently had been detected among eukaryotes in some protists only. There is now evidence for the presence in several other eukaryotes of PPK1 homologues and also a second bacteria-type enzyme, PPK2. The latest genome databases reveal that the 'Kornberg' enzyme complex of three actin-related proteins, termed DdPPK2 in Dictyostelium discoideum, might also be ubiquitous in eukaryotes. Owing to the intimate association of poly P synthesis with the formation of structural fibres, this ubiquity indicates a central role for this molecule in the evolution of eukaryotic cells.Citation
Trends in biochemical sciences, 33 (12):577-82Publisher
ElsevierJournal
Trends in biochemical sciencesPubMed ID
18938082Type
Journal articleLanguage
enISSN
0968-0004ae974a485f413a2113503eed53cd6c53
10.1016/j.tibs.2008.09.007
Scopus Count
Collections
Related articles
- Inorganic polyphosphate in the origin and survival of species.
- Authors: Brown MR, Kornberg A
- Issue date: 2004 Nov 16
- The long and short of it - polyphosphate, PPK and bacterial survival.
- Authors: Brown MR, Kornberg A
- Issue date: 2008 Jun
- Formation of an actin-like filament concurrent with the enzymatic synthesis of inorganic polyphosphate.
- Authors: Gómez-García MR, Kornberg A
- Issue date: 2004 Nov 9
- Inorganic polyphosphate in Dictyostelium discoideum: influence on development, sporulation, and predation.
- Authors: Zhang H, Gómez-García MR, Brown MR, Kornberg A
- Issue date: 2005 Feb 22
- Inorganic polyphosphate: essential for growth and survival.
- Authors: Rao NN, Gómez-García MR, Kornberg A
- Issue date: 2009