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Wolverhampton Intellectual Repository and E-Theses > School of Applied Sciences > Research Centre in Applied Sciences  > Applied Microbiology Research Group > Eukaryote polyphosphate kinases: is the 'Kornberg' complex ubiquitous?

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/117150
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Title: Eukaryote polyphosphate kinases: is the 'Kornberg' complex ubiquitous?
Authors: Hooley, Paul
Whitehead, Michael P.
Brown, Michael R. W.
Citation: Trends in biochemical sciences, 33 (12):577-82
Publisher: Elsevier
Journal: Trends in biochemical sciences
Issue Date: 2008
URI: http://hdl.handle.net/2436/117150
DOI: 10.1016/j.tibs.2008.09.007
PubMed ID: 18938082
Abstract: Polyphosphate (poly P) is a polymer of up to several hundred phosphate residues and is important to a variety of cell processes. The main poly P synthetic enzyme in many bacteria is poly P kinase 1 (PPK1), which until recently had been detected among eukaryotes in some protists only. There is now evidence for the presence in several other eukaryotes of PPK1 homologues and also a second bacteria-type enzyme, PPK2. The latest genome databases reveal that the 'Kornberg' enzyme complex of three actin-related proteins, termed DdPPK2 in Dictyostelium discoideum, might also be ubiquitous in eukaryotes. Owing to the intimate association of poly P synthesis with the formation of structural fibres, this ubiquity indicates a central role for this molecule in the evolution of eukaryotic cells.
Type: Article
Language: en
MeSH: Actins
Amino Acid Sequence
Animals
Bacteria
Computational Biology
Dictyostelium
Drug Design
Eukaryotic Cells
Fungal Proteins
Molecular Sequence Data
Multienzyme Complexes
Phosphotransferases (Phosphate Group Acceptor)
Polyphosphates
Sequence Alignment
ISSN: 0968-0004
Appears in Collections: Applied Microbiology Research Group
Cancer Research Group

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