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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Sport, Exercise and Health Research Group > Comparison between G6PD-Deficient and Normal Individuals after Eccentric Exercise

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/113472
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Title: Comparison between G6PD-Deficient and Normal Individuals after Eccentric Exercise
Authors: Theodorou, Anastasios A.
Nikolaidis, Michalis G.
Paschalis, Vassilis
Sakellariou, Georgios K.
Fatouros, Ioannis G.
Koutedakis, Yiannis
Jamurtas, Athanasios Z.
Citation: Medicine & Science in Sports & Exercise, 42(6) ; 1113-1121
Publisher: American College of Sports Medicine
Journal: Medicine & Science in Sports & Exercise
Issue Date: 2010
URI: http://hdl.handle.net/2436/113472
DOI: 10.1249/MSS.0b013e3181c67ecd
Additional Links: http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00005768-900000000-99360
Abstract: Purpose: Theoretically, glucose-6-phosphate dehydrogenase (G6PD)-deficient compared with nondeficient individuals may be less capable of performing physical activities and/or may be more vulnerable to muscle damage and oxidative stress. Therefore, the purpose of the present study was to examine the effects of a resistance muscle-damaging exercise bout on muscle function and damage, redox status in plasma, and erythrocytes and hemolysis. Methods: Nine males with established G6PD deficiency and nine males with normal G6PD activity performed an eccentric muscledamaging exercise protocol. Isometric torque, range of motion, delayed onset muscle soreness, and creatine kinase were measured as indices of muscle function and damage. Reduced glutathione, oxidized glutathione, thiobarbituric acid–reactive substances, protein carbonyls, catalase, uric acid, and total antioxidant capacity were measured as indices of blood redox status. Plasma hemoglobin and bilirubin were measured as indices of hemolysis. All measurements conducted before, immediately after, and 1, 2, 3, 4, and 5 d after exercise. Results: All indices measured confirmed that eccentric exercise induced severe muscle damage, oxidative stress, and hemolysis, peaking at 2 and 3 d postexercise. Lower resting levels of reduced glutathione were detected in the G6PD-deficient group compared with the control group. Nevertheless, both the time course and the magnitude of the changes of the selected muscle performance, redox status (both in plasma and in erythrocytes), and hemolysis indices measured were similar between the two groups. Conclusions: The present study indicates that G6PD-deficient individuals may participate in high-intensity muscle-damaging activities, without a negative impact on muscle function, blood redox status, and hemolysis
Type: Article
Language: en
Keywords: Free radicals
Lipid peroxidation
Hemolysis
Muscle damage
ISSN: 0195-9131
Appears in Collections: Sport, Exercise and Health Research Group

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