2.50
Hdl Handle:
http://hdl.handle.net/2436/106617
Title:
Acute and short-term effects of secondhand smoke on lung function and cytokine production.
Authors:
Flouris, Andreas D.; Metsios, Giorgos S.; Carrillo, A. E.; Jamurtas, Athanasios Z.; Gourgoulianis, K.; Kiropoulos, Theodoros; Tzatzarakis, M. N.; Tsatsakis, A. M.; Koutedakis, Yiannis
Abstract:
RATIONALE: The acute effect of secondhand smoke (SHS) on lung function and the duration of system disruption remain unknown. OBJECTIVES: To assess the SHS effects and their duration on lung function and inflammatory markers. METHODS: In a randomized single-blind crossover experiment data were obtained from 16 (8 women) nonsmoking adults at baseline and at 0, 1, and 3 hours after a 1-hour SHS exposure set at bar/restaurant SHS levels. MEASUREMENTS AND MAIN RESULTS: Serum and urine cotinine, lung function, and cytokines IL-4, IL-5, IL-6, tumor necrosis factor (TNF)-alpha, and IFN-gamma. At 0 hours most lung function parameters were significantly reduced (indicative: FEV(1), 4.3 +/- 0.4 vs. 3.8 +/- 0.3 L; FEV(1)/FVC, 0.9 +/- 0.1 vs. 0.8 +/- 0.1; P < 0.05) but at 3 hours they were at baseline levels. In contrast, cotinine (serum, 8.9 +/- 3.2 vs. 35.5 +/- 10.2 ng x ml(-1)), IL-4 (41.3 +/- 5.8 vs. 44.2 +/- 4.5 pg x ml(-1)), IL-5 (36.1 +/- 3.2 vs. 60.1 +/- 7.0 pg x ml(-1)), IL-6 (2.5 +/- 0.3 vs. 7.6 +/- 1.4 pg x ml(-1)) and IFN-gamma (0.3 +/- 0.2 vs. 0.6 +/- 0.2 IU x ml(-1)) at 3 hours were higher than at baseline (P < 0.05). IL-4 and TNF-alpha increased only in men, whereas IL-5, IL-6, and IFN-gamma were different between sexes after exposure (P < 0.05). Regression analyses revealed inverse associations of FEV(1) and FEV(1)/FVC ratio with IL-5 (P < 0.05) in men and with IL-5 (P = 0.01), IL-6 (P < 0.001), IFN-gamma (P = 0.034) and serum cotinine (P < 0.001) in women. CONCLUSIONS: We conclude that 1 hour of SHS exposure at bar/restaurant levels is accompanied by significant decrements on lung function and marked increases in inflammatory cytokines, particularly in men. More importantly, whereas most smoke-induced effects on lung function appear to recede within 60 minutes, inflammatory cytokines remain elevated for at least 3 hours after exposure to SHS.
Citation:
American journal of respiratory and critical care medicine, 179(11):1029-33
Publisher:
American Thoracic Society
Journal:
American journal of respiratory and critical care medicine
Issue Date:
2009
URI:
http://hdl.handle.net/2436/106617
DOI:
10.1164/rccm.200812-1920OC
PubMed ID:
19264972
Additional Links:
http://proquest.umi.com/pqdlink?index=0&did=1727325771&SrchMode=3&sid=1&Fmt=3&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1276866378&clientId=53702&aid=1
Type:
Article
Language:
en
ISSN:
1535-4970
Appears in Collections:
Exercise and Health

Full metadata record

DC FieldValue Language
dc.contributor.authorFlouris, Andreas D.en
dc.contributor.authorMetsios, Giorgos S.en
dc.contributor.authorCarrillo, A. E.en
dc.contributor.authorJamurtas, Athanasios Z.en
dc.contributor.authorGourgoulianis, K.en
dc.contributor.authorKiropoulos, Theodorosen
dc.contributor.authorTzatzarakis, M. N.en
dc.contributor.authorTsatsakis, A. M.en
dc.contributor.authorKoutedakis, Yiannisen
dc.date.accessioned2010-06-22T09:09:51Z-
dc.date.available2010-06-22T09:09:51Z-
dc.date.issued2009-
dc.identifier.citationAmerican journal of respiratory and critical care medicine, 179(11):1029-33en
dc.identifier.issn1535-4970-
dc.identifier.pmid19264972-
dc.identifier.doi10.1164/rccm.200812-1920OC-
dc.identifier.urihttp://hdl.handle.net/2436/106617-
dc.description.abstractRATIONALE: The acute effect of secondhand smoke (SHS) on lung function and the duration of system disruption remain unknown. OBJECTIVES: To assess the SHS effects and their duration on lung function and inflammatory markers. METHODS: In a randomized single-blind crossover experiment data were obtained from 16 (8 women) nonsmoking adults at baseline and at 0, 1, and 3 hours after a 1-hour SHS exposure set at bar/restaurant SHS levels. MEASUREMENTS AND MAIN RESULTS: Serum and urine cotinine, lung function, and cytokines IL-4, IL-5, IL-6, tumor necrosis factor (TNF)-alpha, and IFN-gamma. At 0 hours most lung function parameters were significantly reduced (indicative: FEV(1), 4.3 +/- 0.4 vs. 3.8 +/- 0.3 L; FEV(1)/FVC, 0.9 +/- 0.1 vs. 0.8 +/- 0.1; P < 0.05) but at 3 hours they were at baseline levels. In contrast, cotinine (serum, 8.9 +/- 3.2 vs. 35.5 +/- 10.2 ng x ml(-1)), IL-4 (41.3 +/- 5.8 vs. 44.2 +/- 4.5 pg x ml(-1)), IL-5 (36.1 +/- 3.2 vs. 60.1 +/- 7.0 pg x ml(-1)), IL-6 (2.5 +/- 0.3 vs. 7.6 +/- 1.4 pg x ml(-1)) and IFN-gamma (0.3 +/- 0.2 vs. 0.6 +/- 0.2 IU x ml(-1)) at 3 hours were higher than at baseline (P < 0.05). IL-4 and TNF-alpha increased only in men, whereas IL-5, IL-6, and IFN-gamma were different between sexes after exposure (P < 0.05). Regression analyses revealed inverse associations of FEV(1) and FEV(1)/FVC ratio with IL-5 (P < 0.05) in men and with IL-5 (P = 0.01), IL-6 (P < 0.001), IFN-gamma (P = 0.034) and serum cotinine (P < 0.001) in women. CONCLUSIONS: We conclude that 1 hour of SHS exposure at bar/restaurant levels is accompanied by significant decrements on lung function and marked increases in inflammatory cytokines, particularly in men. More importantly, whereas most smoke-induced effects on lung function appear to recede within 60 minutes, inflammatory cytokines remain elevated for at least 3 hours after exposure to SHS.en
dc.language.isoenen
dc.publisherAmerican Thoracic Societyen
dc.relation.urlhttp://proquest.umi.com/pqdlink?index=0&did=1727325771&SrchMode=3&sid=1&Fmt=3&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1276866378&clientId=53702&aid=1en
dc.subjectPassive smokingen
dc.subjectCotinineen
dc.subjectRespirationen
dc.subjectInflammatory markersen
dc.subject.meshAdulten
dc.subject.meshBiological Markersen
dc.subject.meshCotinineen
dc.subject.meshCross-Over Studiesen
dc.subject.meshCytokinesen
dc.subject.meshEnvironmental Monitoringen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshRespiratory Function Testsen
dc.subject.meshSex Distributionen
dc.subject.meshSingle-Blind Methoden
dc.subject.meshTobacco Smoke Pollutionen
dc.subject.meshYoung Adulten
dc.titleAcute and short-term effects of secondhand smoke on lung function and cytokine production.en
dc.typeArticleen
dc.identifier.journalAmerican journal of respiratory and critical care medicineen

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