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Wolverhampton Intellectual Repository and E-Theses > School of Sport, Performing Arts and Leisure > Research Centre for Sport, Exercise and Performance > Exercise and Health > Acute and short-term effects of secondhand smoke on lung function and cytokine production.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/106617
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Title: Acute and short-term effects of secondhand smoke on lung function and cytokine production.
Authors: Flouris, Andreas D.
Metsios, Giorgos S.
Carrillo, A. E.
Jamurtas, Athanasios Z.
Gourgoulianis, K.
Kiropoulos, Theodoros
Tzatzarakis, M. N.
Tsatsakis, A. M.
Koutedakis, Yiannis
Citation: American journal of respiratory and critical care medicine, 179(11):1029-33
Publisher: American Thoracic Society
Journal: American journal of respiratory and critical care medicine
Issue Date: 2009
URI: http://hdl.handle.net/2436/106617
DOI: 10.1164/rccm.200812-1920OC
PubMed ID: 19264972
Additional Links: http://proquest.umi.com/pqdlink?index=0&did=1727325771&SrchMode=3&sid=1&Fmt=3&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1276866378&clientId=53702&aid=1
Abstract: RATIONALE: The acute effect of secondhand smoke (SHS) on lung function and the duration of system disruption remain unknown. OBJECTIVES: To assess the SHS effects and their duration on lung function and inflammatory markers. METHODS: In a randomized single-blind crossover experiment data were obtained from 16 (8 women) nonsmoking adults at baseline and at 0, 1, and 3 hours after a 1-hour SHS exposure set at bar/restaurant SHS levels. MEASUREMENTS AND MAIN RESULTS: Serum and urine cotinine, lung function, and cytokines IL-4, IL-5, IL-6, tumor necrosis factor (TNF)-alpha, and IFN-gamma. At 0 hours most lung function parameters were significantly reduced (indicative: FEV(1), 4.3 +/- 0.4 vs. 3.8 +/- 0.3 L; FEV(1)/FVC, 0.9 +/- 0.1 vs. 0.8 +/- 0.1; P < 0.05) but at 3 hours they were at baseline levels. In contrast, cotinine (serum, 8.9 +/- 3.2 vs. 35.5 +/- 10.2 ng x ml(-1)), IL-4 (41.3 +/- 5.8 vs. 44.2 +/- 4.5 pg x ml(-1)), IL-5 (36.1 +/- 3.2 vs. 60.1 +/- 7.0 pg x ml(-1)), IL-6 (2.5 +/- 0.3 vs. 7.6 +/- 1.4 pg x ml(-1)) and IFN-gamma (0.3 +/- 0.2 vs. 0.6 +/- 0.2 IU x ml(-1)) at 3 hours were higher than at baseline (P < 0.05). IL-4 and TNF-alpha increased only in men, whereas IL-5, IL-6, and IFN-gamma were different between sexes after exposure (P < 0.05). Regression analyses revealed inverse associations of FEV(1) and FEV(1)/FVC ratio with IL-5 (P < 0.05) in men and with IL-5 (P = 0.01), IL-6 (P < 0.001), IFN-gamma (P = 0.034) and serum cotinine (P < 0.001) in women. CONCLUSIONS: We conclude that 1 hour of SHS exposure at bar/restaurant levels is accompanied by significant decrements on lung function and marked increases in inflammatory cytokines, particularly in men. More importantly, whereas most smoke-induced effects on lung function appear to recede within 60 minutes, inflammatory cytokines remain elevated for at least 3 hours after exposure to SHS.
Type: Article
Language: en
Keywords: Passive smoking
Cotinine
Respiration
Inflammatory markers
MeSH: Adult
Biological Markers
Cotinine
Cross-Over Studies
Cytokines
Environmental Monitoring
Female
Humans
Male
Respiratory Function Tests
Sex Distribution
Single-Blind Method
Tobacco Smoke Pollution
Young Adult
ISSN: 1535-4970
Appears in Collections: Exercise and Health

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